ReviewCurrent opinion in neurobiology2012
Tethering toxins and peptide ligands for modulation of neuronal function.
Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- A genetically encoded secreted toxin potentiates synaptic NMDA receptors in hippocampal neurons and confers neuroprotection.PNAS nexus · 2025Article
- Local modulation by presynaptic receptors controls neuronal communication and behaviour.Nature reviews. Neuroscience · 2022Review
- Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches.RSC chemical biology · 2022Review
- Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.Journal of the American Chemical Society · 2019Article
- From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs.Frontiers in pharmacology · 2019Article
- Similar molecular determinants on Rem mediate two distinct modes of inhibition of CaChannels (Austin, Tex.) · 2016Article
- Review
- Ion channel engineering: perspectives and strategies.Journal of molecular biology · 2015Review
- Molecular neuroanatomy: a generation of progress.Trends in neurosciences · 2014Review
- Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.Advanced functional materials · 2014Article
- New rule(r)s for FRET.Biophysical journal · 2013Article
- Article
- Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila G protein-coupled receptor rickets.Molecular pharmacology · 2013Article
- Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Review
- The genetic analysis of functional connectomics in Drosophila.Advances in genetics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Tethering genetically encoded peptide toxins or ligands close to their point of activity at the cell plasma membrane provides a new approach to the study of cell networks and neuronal circuits, as it allows selective targeting of specific cell populations, enhances the working concentration of the ligand or blocker peptide, and permits the engineering of a large variety of t-peptides (e.g., including use of fluorescent markers, viral vectors and point mutation variants). This review describes the development of tethered toxins (t-toxins) and peptides derived from the identification of the cell surface nicotinic acetylcholine receptor (nAChR) modulator lynx1, the existence of related endogenous cell surface modulators of nAChR and AMPA receptors, and the application of the t-toxin and t-neuropeptide technology to the dissection of neuronal circuits in metazoans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.