Evidence map›Paper›PMID 22119141›Full record

ReviewCurrent opinion in neurobiology2012

Genetics in non-genetic model systems.

Carlos Lois, James O Groves

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Genome engineering: Drosophila melanogaster and beyond.Wiley interdisciplinary reviews. Developmental biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carlos LoisDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, 364 Plantation Street, MA 01655, USA. Carlos.Lois@umassmed.edu
James O Groves

Funding

Transgenesis in songbirds for the genetic manipulation of neuronal circuitsR24GM089700 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LOIS, CARLOS · 2011 to 2014
$1.3M
NIGMS NIH HHS R24 GM089700
6 · The paper itself

Abstract

The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C. elegans, zebrafish and mouse, remains relatively few. This review will discuss the variety of approaches to genetic modification that have been developed in such traditional 'genetic systems', and highlight the progress that has been made to translate these technologies to alternative species such as rats, monkeys and birds, where certain neurobiological questions may be better studied.

Indexed as

AnimalsGenetic EngineeringModels, BiologicalNeurosciences

Identifiers

PMID22119141
PMCPMC3320209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.