Evidence map›Paper›PMID 22119110›Full record

ReviewCurrent opinion in immunology2011

B cells and autoimmunity.

Shiv Pillai, Hamid Mattoo, Annaiah Cariappa

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 114 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Immune dysregulation in immunoglobulin G4-related disease.The Japanese dental science review · 2023
    Review
  7. The role ofFrontiers in immunology · 2023
    Review
  8. Article
  9. Science advances · 2021
    Article
  10. Lower BAFF Levels in Myasthenic Patients Treated with Glucocorticoids.Archivum immunologiae et therapiae experimentalis · 2021
    Article
  11. Review
  12. Regulatory B cells in cancer.Immunological reviews · 2021
    Review
  13. Article
  14. Article
  15. B lymphocytes directly contribute to tissue fibrosis in patients with IgGThe Journal of allergy and clinical immunology · 2020
    Article
  16. Review of a novel disease entity, immunoglobulin G4-related disease.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shiv PillaiCenter for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States. pillai@helix.mgh.harvard.edu
Hamid Mattoo
Annaiah Cariappa
Harvard University · US

Funding

Studies on Peripheral B Lymphocyte DevelopmentR01AI064930 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2006 to 2016
$3.9M
Inducing neutralizing antibodies to HIV by inhibiting SIAER01AI090867 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2010 to 2013
$2.8M
Mutations in the SIAE Gene and Susceptibility to Autoimmune DiseasesR01AI076505 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2009 to 2012
$1.8M
Functionally Linking Autoimmune Subjects to Novel Therapies Using BiomarkersRC1AR058481 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2009 to 2010
$997k
Human Memory B cells in Humanized MiceR21AI088478 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2010 to 2011
$485k
NIAID NIH HHS AI064930NIAID NIH HHS AI076505NIAID NIH HHS R01 AI064930NIAID NIH HHS R01 AI076505NIAID NIH HHS R01 AI090867NIAID NIH HHS R21 AI088478NIAMS NIH HHS AR058481NIAMS NIH HHS RC1 AR058481
6 · The paper itself

Abstract

There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed.

Indexed as

AutoimmunityAnimalsB-Cell Activating FactorB-LymphocytesHumansImmune ToleranceImmunologic MemorySignal TransductionB-Cell Activating Factor

Identifiers

PMID22119110
PMCPMC3268048
OpenAlexW1979091308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.