ArticleJournal of affective disorders2012
Recent life events pose greatest risk for onset of major depressive disorder during mid-life.
Article in Journal of affective disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prevalence and correlates of major depressive disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Thriving Through Stressful Life Events with Nature: A Mixed-Method Study on Tending Indoor Plants and Rumination Resilience.International journal of environmental research and public health · 2025Trial
- Risk factors for major depressive disorder among adults recruited from hospital settings in Uganda, Kenya, Ethiopia and South Africa.Nature communications · 2026Article
- Social position and antidepressant dose trajectories: a latent class analysis of a french cohort linked to the reimbursement register.Social psychiatry and psychiatric epidemiology · 2026Article
- Mental health in adults aged 50+ since the COVID-19 pandemic: Are we (all) back to 'normal'? evidence from England.Journal of affective disorders reports · 2026Article
- Biopsychosocial Response to the COVID-19 Lockdown in People with Major Depressive Disorder and Multiple Sclerosis.Journal of clinical medicine · 2022Article
- Stigma, depression, and anxiety among patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Psychological pain and suicidal behavior: A review.Frontiers in psychiatry · 2022Review
- Depression, health comorbidities, cognitive symptoms and their functional impact: Not just a geriatric problem.Journal of psychiatric research · 2021Article
- The association between dopamine receptor (DRD4) gene polymorphisms and second language learning style and behavioral variability in undergraduate students in Turkey.Molecular biology reports · 2014Article
- Risk factors for onset of multiple or long major depressive episodes versus single and short episodes.Social psychiatry and psychiatric epidemiology · 2013Article
- Differential impact of risk factors for women and men on the risk of major depressive disorder.Annals of epidemiology · 2012Article
- Number of significant life events and perinatal depression in a diverse rural population: A brief report of a cross-sectional study.Women's health (London, England)Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 7 countries.
Funding
Abstract
backgroundThe authors examined an additive model for the association of life events and age with onset of major depressive disorder (MDD) and whether the combination of life events and age posed greater risk than the sum of their independent effects.
methodsData were used from a prospective cohort study of 10,045 general practice attendees (PredictD). We included those without MDD at baseline (N=8293). We examined age divided into tertiles and into 10 year groups. Life events were assessed at baseline using the List of Threatening Life Experiences Questionnaire and categorized according to type. Main outcome measure was onset of DSM-IV MDD at 6 or 12 months of follow-up. The authors calculated Relative Excess Risks due to Interaction (RERI).
results6910 persons (83.3%) had a complete follow-up, of whom 589 (8.5%) had an onset of MDD (166 younger, 254 middle aged and 169 older). The combined effect of personal problems (RERI=1.30; 95% CI 0.29 to 2.32), events in family or friends (RERI=1.23; 95% CI 0.28 to 2.19), or problems with law (RERI=1.57; 95% CI 0.33 to 2.82) and middle age was larger than the sum of individual effects. LIMITATIONS: Lower response to recruitment in the UK and the Netherlands.
conclusionsRecent life events carry the largest risk of onset of MDD in mid-life. Understanding the different vulnerability to life events according to age may help to indicate groups at a particular risk and assist in preventive strategies.
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