ReviewTrends in neurosciences2012
Fear conditioning and extinction: emotional states encoded by distinct signaling pathways.
Review in Trends in neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed.
- Local Neuronal Ensembles That Coreactivate across Regions during Sleep Are Preferentially Stabilized.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1.Biological psychiatry global open science · 2025Article
- Article
- Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery.Neurobiology of stress · 2025Article
- Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence.Neuroscience and biobehavioral reviews · 2025Review
- Extinction of contextual fear memory is facilitated in TRPM2 knockout mice.Molecular brain · 2025Article
- No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Activation of ACE2/Ang-(1-7)/Mas axis improves cognitive dysfunction induced by isoflurane in mice via inhibiting oxidative stress.Journal of anesthesia and translational medicine · 2024Article
- Article
- Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala.Science advances · 2023Article
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Fear-potentiated startle reveals diminished threat extinction in pathological anxiety.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Unconditioned and conditioned anxiolytic effects of Sodium Valproate on flavor neophobia and fear conditioning.PloS one · 2023Article
- Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear.Molecular psychiatry · 2022Article
- A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults.Journal of neuroscience research · 2022Article
- Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biological psychiatry · 2022Review
- Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.Frontiers in cellular neuroscience · 2022Article
- Three genetic-environmental networks for human personality.Molecular psychiatry · 2021Article
- Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.Acta neuropathologica communications · 2021Article
- Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala.Frontiers in cellular neuroscience · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Conditioning and extinction of fear have traditionally been viewed as two independent learning processes for encoding representations of contexts or cues (conditioned stimuli, CS), aversive events (unconditioned stimuli, US), and their relationship. Based on the analysis of protein kinase signaling patterns in neurons of the fear circuit, we propose that fear and extinction are best conceptualized as emotional states triggered by a single CS representation with two opposing values: aversive and non-aversive. These values are conferred by the presence or absence of the US and encoded by distinct sets of kinase signaling pathways and their downstream targets. Modulating specific protein kinases thus has the potential to modify emotional states, and hence, may emerge as a promising treatment for anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.