Trial reportJournal of psychiatric research2012
Depression beliefs, treatment preference, and outcomes in a randomized trial for major depressive disorder.
Trial report in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The impact of patient choice on uptake, adherence, and outcomes across depression, anxiety, and eating disorders: a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Association of Patient Treatment Preference With Dropout and Clinical Outcomes in Adult Psychosocial Mental Health Interventions: A Systematic Review and Meta-analysis.JAMA psychiatry · 2020Pooled it
- Client preferences affect treatment satisfaction, completion, and clinical outcome: a meta-analysis.Clinical psychology review · 2014Pooled it
- Adherence to Internet-based and face-to-face cognitive behavioural therapy for depression: a meta-analysis.PloS one · 2014Pooled it
- Benefits of Sequentially Adding Cognitive-Behavioral Therapy or Antidepressant Medication for Adults With Nonremitting Depression.The American journal of psychiatry · 2019Trial
- Effects of Patient Preferences on Outcomes in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) Study.The American journal of psychiatry · 2017Trial
- A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression.Psychotherapy and psychosomatics · 2016Trial
- Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression.The Journal of neuropsychiatry and clinical neurosciences · 2015Trial
- Pretreatment brain states identify likely nonresponse to standard treatments for depression.Biological psychiatry · 2014Trial
- Choosing between Internet-based psychodynamic versus cognitive behavioral therapy for depression: a pilot preference study.BMC psychiatry · 2013Trial
- Toward a neuroimaging treatment selection biomarker for major depressive disorder.JAMA psychiatry · 2013Trial
- Trial
- Are Veterans Getting Their Preferred Depression Treatment? A National Observational Study in the Veterans Health Administration.Journal of general internal medicine · 2022Observational
- A Randomized Preference Trial Comparing Cognitive-Behavioral Therapy and Yoga for the Treatment of Late-Life Worry: Examination of Impact on Depression, Generalized Anxiety, Fatigue, Pain, Social Participation, and Physical Function.Global advances in health and medicine · 2022Article
- Establishing Evidence for Clinical Utility of a Neuroimaging Biomarker in Major Depressive Disorder: Prospective Testing and Implementation Challenges.Biological psychiatry · 2021Article
- A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- The symptom-specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: results from an individual patient data meta-analysis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- The role of depression pharmacogenetic decision support tools in shared decision making.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Preferences for Depression Treatment Including Internet-Based Interventions: Results From a Large Sample of Primary Care Patients.Frontiers in psychiatry · 2018Article
- The three-legged stool of evidence-based practice in eating disorder treatment: research, clinical, and patient perspectives.BMC medicine · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Previous studies suggest that individual preferences for medication- or psychotherapy-based treatments for depression may affect outcomes in clinical trials that compare these two forms of treatment. We assessed patients' beliefs about the causes of their depression, their preferred treatment, and strength of that preference in 80 patients participating in a 12-week clinical trial evaluating neuroimaging predictors of response to cognitive behavior therapy (CBT) or escitalopram. Forty-five patients expressed a preference for one of the 2 treatments, but being matched to preference did not influence remission or completion rates. Medication-preferring patients were more likely to terminate the trial early, regardless of treatment received. CBT-preferring patients rarely endorsed unknown causes for their depression, and medication-preferring patients were highly unlikely to identify pessimistic attitudes as a source of their depression. Among patients willing to be randomized to treatment, preference does not appear to strongly influence outcome. Specific preferences for CBT or medication may reflect differing conceptualizations about depressive illness, knowledge of which may enhance treatment retention and efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.