ArticleJournal of child psychology and psychiatry, and allied disciplines2012
Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Face processing in young adults with autism and ADHD: An event related potentials study.Frontiers in psychiatry · 2023Article
- What Has Been Learned from Using EEG Methods in Research of ADHD?Current topics in behavioral neurosciences · 2022Article
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission.Journal of attention disorders · 2020Article
- Article
- Impairments in error processing and their association with ADHD symptoms in individuals born preterm.PloS one · 2019Article
- Association of preterm birth with ADHD-like cognitive impairments and additional subtle impairments in attention and arousal malleability.Psychological medicine · 2018Article
- Altered EEG spectral power during rest and cognitive performance: a comparison of preterm-born adolescents to adolescents with ADHD.European child & adolescent psychiatry · 2017Article
- Neurophysiological Correlates of Attentional Fluctuation in Attention-Deficit/Hyperactivity Disorder.Brain topography · 2017Article
- Association of Preterm Birth With Attention-Deficit/Hyperactivity Disorder-Like and Wider-Ranging Neurophysiological Impairments of Attention and Inhibition.Journal of the American Academy of Child and Adolescent Psychiatry · 2017Article
- Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- A comparison of machine learning methods for classification using simulation with multiple real data examples from mental health studies.Statistical methods in medical research · 2016Article
- The aetiological association between the dynamics of cortisol productivity and ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Cognitive and neurophysiological markers of ADHD persistence and remission.The British journal of psychiatry : the journal of mental science · 2016Article
- The molecular genetic architecture of attention deficit hyperactivity disorder.Molecular psychiatry · 2015Review
- Genetic overlap between evoked frontocentral theta-band phase variability, reaction time variability, and attention-deficit/hyperactivity disorder symptoms in a twin study.Biological psychiatry · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAttention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder.
methodsDirect-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozygotic and dizygotic matched-control twin pairs with low ADHD symptom scores. Structural equation modelling was used to quantify the genetic and environmental contributions to the phenotypic covariance between ADHD and VLF activity.
resultsAttention deficit hyperactivity disorder was significantly associated with reduced VLF power during cognitive activation, which suggests reduced synchronization of widespread neuronal activity. Very low-frequency power demonstrated modest heritability (0.31), and the genetic correlation (-0.80) indicated a substantial degree of overlap in genetic influences on ADHD and VLF activity.
conclusionsAltered VLF activity is a potential candidate intermediate phenotype of ADHD, which warrants further investigation of underlying neurobiological and genetic mechanisms.
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