ArticleBMC complementary and alternative medicine2011
In vitro activities of natural products against oral Candida isolates from denture wearers.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 132 citations in OpenAlex.
- Beneficial Effect of Olive Leaf Extract as an Adjunct to Standard Antifungal Therapy in TreatingInternational journal of molecular sciences · 2025Trial
- Antimicrobial activity, ergosterol content and phytochemical screening of Rorippa Islandica (Oeder ex Murr.) and Carrichtera annua (L.).Scientific reports · 2025Article
- Linalool combatseLife · 2025Article
- Comparison of herbal products with antifungal drugs in cure of oral candidiasis: A systematic review.Dental research journal · 2025Review
- Lipid nanocarrier containing eugenol for denture hygiene: evaluation of efficacy against Candida biofilms.Journal of applied oral science : revista FOB · 2025Article
- Benzyldimethyldodecyl Ammonium Chloride-Doped Denture-Based Resin: Impact on Strength, Surface Properties, Antifungal Activities, and In Silico Molecular Docking Analysis.Journal of functional biomaterials · 2024Article
- Antimicrobial Activity of Olive Leaf Extract to OralMicroorganisms · 2024Article
- Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion.Pharmaceutics · 2023Article
- In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole againstJournal of fungi (Basel, Switzerland) · 2023Article
- Zerumbone Disturbs the Extracellular Matrix of Fluconazole-ResistantJournal of fungi (Basel, Switzerland) · 2023Article
- The Role ofPathogens (Basel, Switzerland) · 2022Article
- Antibiotic properties of Satureja montana L. hydrolate in bacteria and fungus of clinical interest and its impact in non-target environmental microorganisms.Scientific reports · 2022Article
- Autotoxicity of Endogenous Organic Acid Stress in TwoMolecules (Basel, Switzerland) · 2022Article
- Antifungal Activity ofMolecules (Basel, Switzerland) · 2022Article
- Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections.Microorganisms · 2022Article
- Eugenol: A novel therapeutic agent for the inhibition ofFrontiers in pharmacology · 2022Review
- The in-vitro effects of white henna addition on the Candida albicans adhesion and physical properties of denture base resin.European oral research · 2021Article
- Mechanistic Understanding ofFrontiers in microbiology · 2021Review
- Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Role of symbiosis in the discovery of novel antibiotics.The Journal of antibiotics · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCandida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils.
methodsEight terpenic derivatives (carvacrol, farnesol, geraniol, linalool, menthol, menthone, terpinen-4-ol, and α-terpineol), a phenylpropanoid (eugenol), a phenethyl alcohol (tyrosol) and fluconazole were evaluated against 38 Candida isolated from denture-wearers and 10 collection Candida strains by the CLSI M27-A3 broth microdilution method.
resultsAlmost all the tested compounds showed antifungal activity with MIC ranges of 0.03-0.25% for eugenol and linalool, 0.03-0.12% for geraniol, 0.06-0.5% for menthol, α-terpineol and terpinen-4-ol, 0.03-0.5% for carvacrol, and 0.06-4% for menthone. These compounds, with the exception of farnesol, menthone and tyrosol, showed important in vitro activities against the fluconazole-resistant and susceptible-dose dependent Candida isolates.
conclusionsCarvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Their fungistatic and fungicidal activities might convert them into promising alternatives for the topic treatment of oral candidiasis and denture stomatitis.
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