ArticleThe EMBO journal2011
PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- miRNA-mediated gene silencing in Drosophila larval development involves GW182-dependent and independent mechanisms.The EMBO journal · 2024Article
- Single-molecule imaging of microRNA-mediated gene silencing in cells.Nature communications · 2022Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.Frontiers in bioscience (Landmark edition) · 2020Review
- eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.Genome biology · 2019Article
- Mechanistic Insights into MicroRNA-Mediated Gene Silencing.Cold Spring Harbor perspectives in biology · 2019Review
- ATP is dispensable for both miRNA- and Smaug-mediated deadenylation reactions.RNA (New York, N.Y.) · 2017Article
- Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.PLoS genetics · 2017Article
- CCR4 and CAF1 deadenylases have an intrinsic activity to remove the post-poly(A) sequence.RNA (New York, N.Y.) · 2016Article
- Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.Nucleic acids research · 2016Article
- Article
- RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions.Biomolecules · 2015Review
- Towards a molecular understanding of microRNA-mediated gene silencing.Nature reviews. Genetics · 2015Review
- Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast.The Journal of biological chemistry · 2015Article
- The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins.RNA biology · 2015Review
- The complexity of miRNA-mediated repression.Cell death and differentiation · 2015Review
- HIV-associated neuropathogenesis: a systems biology perspective for modeling and therapy.Bio Systems · 2014Review
- Elements and machinery of non-coding RNAs: toward their taxonomy.EMBO reports · 2014Review
- Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.Frontiers in genetics · 2014Review
- A role for eIF4AII in microRNA-mediated mRNA silencing.Nature structural & molecular biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs silence their complementary target genes via formation of the RNA-induced silencing complex (RISC) that contains an Argonaute (Ago) protein at its core. It was previously proposed that GW182, an Ago-associating protein, directly binds to poly(A)-binding protein (PABP) and interferes with its function, leading to silencing of the target mRNAs. Here we show that Drosophila Ago1-RISC induces silencing via two independent pathways: shortening of the poly(A) tail and pure repression of translation. Our data suggest that although PABP generally modulates poly(A) length and translation efficiency, neither PABP function nor GW182-PABP interaction is a prerequisite for these two silencing pathways. Instead, we propose that each of the multiple functional domains within GW182 has a potential for silencing, and yet they need to act together in the context of full-length GW182 to exert maximal silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.