Trial reportDrugs & aging2011
Is there a predictive profile for clinical inertia in hypertensive patients? An observational, cross-sectional, multicentre study.
Trial report in Drugs & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01826929 (Effectiveness of a New Health Care Organization Model in Primary Care for Chronic Cardiovascular Disease Patients Based on a Multifactorial Intervention), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a New Health Care Organization Model in Primary Care for Chronic Cardiovascular Disease Patients Based on a Multifactorial Intervention: The PROPRESE Randomized Controlled Trial.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Clinical inertia in the pharmacological management of hypertension: A systematic review and meta-analysis.Medicine · 2018Pooled it
- The concept and definition of therapeutic inertia in hypertension in primary care: a qualitative systematic review.BMC family practice · 2014Pooled it
- Safety and efficacy of a cardiovascular polypill in people at high and very high risk without a previous cardiovascular event: the international VULCANO randomised clinical trial.BMC cardiovascular disorders · 2022Trial
- Effectiveness of a new health care organization model in primary care for chronic cardiovascular disease patients based on a multifactorial intervention: the PROPRESE randomized controlled trial.BMC health services research · 2013Trial
- Cardiovascular risk assessment and risk factor control in patients with hypertension in Europe: the SNAPSHOT study.European heart journal. Quality of care & clinical outcomes · 2026Observational
- Barriers to effective hypertension control in a low-income healthcare setting: The role of therapeutic inertia and its predictors among hypertensive outpatients.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Therapeutic inertia and contributing factors among ambulatory patients with hypertension.BMC cardiovascular disorders · 2024Observational
- Persistent Cardiometabolic Health Gaps: Can Therapeutic Care Gaps Be Precisely Identified from Electronic Health Records.Healthcare (Basel, Switzerland) · 2021Article
- Clinical inertia remains a problem.Drugs & aging · 2011Article
- Clinical Inertia: A Wider Perspective and Proposed Classification Criteria.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome studies have described a large number of hypertensive patients who are followed by a primary care physician without achieving adequate blood pressure (BP) control but whose treatment nevertheless is not intensified. It is not known whether physicians are aware of this clinical inertia and what factors are associated with this problem.
objectiveThe aim of this study was to describe the factors associated with clinical inertia in hypertensive patients.
methodsThis was an observational, cross-sectional, multicentre study conducted in a network of primary care centres and hospital hypertension units in Spain. Using a consecutive sampling approach, 512 physicians selected 5077 hypertensive patients in whom they suspected poor BP control after chart review. The main variables documented were BP control and cardiovascular risk according to European Society of Hypertension guidelines, changes in treatment after visit, type of treatment, and healthcare setting. A binomial logistic regression multivariate analysis, adjusted for physician, was performed.
resultsOf the selected patients, 70.9% had poor BP control according to measurements taken in the physician's office, and in 1499 (42.1%) of those poorly controlled patients, treatment was not intensified (clinical inertia). Factors associated with clinical inertia were as follows: being seen at a primary care centre (p < 0.001), not having left ventricular hypertrophy (p < 0.001) or microalbuminuria (p < 0.001), taking fixed-dose (p = 0.049) or free-dose (p = 0.001) combination therapy, BP measured in other settings (nurse's office, patient's home) than the physician's office (p = 0.034) or the pharmacy (p = 0.019), older age (p = 0.032), and lower systolic (p < 0.001) and diastolic (p < 0.001) BP. Of the hypertensive patients with clinical inertia, 90.2% (95% CI 88.7, 91.7) had high cardiovascular risk.
conclusionsClinical inertia was associated with a profile that included older age, lack of co-morbid conditions and being seen at a primary care centre.
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