ArticleThe Journal of biological chemistry2012
Streptococcus pyogenes in human plasma: adaptive mechanisms analyzed by mass spectrometry-based proteomics.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- Proteomic Approaches to Unravel Mechanisms of Antibiotic Resistance and Immune Evasion of Bacterial Pathogens.Frontiers in medicine · 2022Review
- Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes.mSystems · 2021Article
- Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria-human protein interactions.Medical microbiology and immunology · 2020Review
- A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies.Nature communications · 2019Article
- Rapid determination of quaternary protein structures in complex biological samples.Nature communications · 2019Article
- Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenes.Scientific reports · 2018Article
- Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.PLoS neglected tropical diseases · 2017Article
- A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteus.Journal of bacteriology · 2017Article
- Targeted Proteomics and Absolute Protein Quantification for the Construction of a Stoichiometric Host-Pathogen Surface Density Model.Molecular & cellular proteomics : MCP · 2017Article
- SCM, the M Protein ofFrontiers in cellular and infection microbiology · 2017Article
- Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis.Infection and immunity · 2016Article
- OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data.Nature biotechnology · 2014Article
- A novel role for pro-coagulant microvesicles in the early host defense against streptococcus pyogenes.PLoS pathogens · 2013Article
- Automated selected reaction monitoring software for accurate label-free protein quantification.Journal of proteome research · 2012Article
- Proteome-wide selected reaction monitoring assays for the human pathogen Streptococcus pyogenes.Nature communications · 2012Article
- openBIS: a flexible framework for managing and analyzing complex data in biology research.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pyogenes is a major bacterial pathogen and a potent inducer of inflammation causing plasma leakage at the site of infection. A combination of label-free quantitative mass spectrometry-based proteomics strategies were used to measure how the intracellular proteome homeostasis of S. pyogenes is influenced by the presence of human plasma, identifying and quantifying 842 proteins. In plasma the bacterium modifies its production of 213 proteins, and the most pronounced change was the complete down-regulation of proteins required for fatty acid biosynthesis. Fatty acids are transported by albumin (HSA) in plasma. S. pyogenes expresses HSA-binding surface proteins, and HSA carrying fatty acids reduced the amount of fatty acid biosynthesis proteins to the same extent as plasma. The results clarify the function of HSA-binding proteins in S. pyogenes and underline the power of the quantitative mass spectrometry strategy used here to investigate bacterial adaptation to a given environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.