ArticleBlood2012
Transfusion-related acute lung injury: incidence and risk factors.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04153487 (Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury), which is not on this map. Cited by 181 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury
Who cites it
181 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Transfusion thresholds and other strategies for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2025Pooled it
- Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022Pooled it
- Transfusion thresholds for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2021Pooled it
- The Effect of Alcohol Consumption on the Risk of ARDS: A Systematic Review and Meta-Analysis.Chest · 2018Pooled it
- Behaviour modification interventions to optimise red blood cell transfusion practices: a systematic review and meta-analysis.BMJ open · 2018Pooled it
- Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.The Cochrane database of systematic reviews · 2016Pooled it
- Transfusion-related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial.Transfusion · 2026Trial
- Aged versus fresh autologous platelet transfusion in a two-hit healthy volunteer model of transfusion-related acute lung injury.Transfusion · 2022Trial
- Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).Annals of the American Thoracic Society · 2022Trial
- A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.Anesthesiology · 2015Trial
- Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial.Critical care (London, England) · 2015Trial
- Transfusion-related acute lung injury-associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2.Transfusion · 2014Trial
- Alcohol screening scores and 90-day outcomes in patients with acute lung injury.Critical care medicine · 2013Trial
- Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.Anesthesia and analgesia · 2012Trial
- Is acute respiratory distress syndrome a preventable disease?Intensive care medicine · 2026Review
- Vancomycin Protects Against Lung Injury and Promotes Butyrate Metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- An assessment of green plasma: The in vitro hemostatic superiority of a currently discarded blood product.Transfusion · 2026Article
- Beyond histocompatibility: human leukocyte antigen as a cross-disciplinary platform for immune recognition and clinical decision-making.Frontiers in immunology · 2026Review
- Mouse Models of Transfusion-Related Acute Lung Injury (TRALI).Methods in molecular biology (Clifton, N.J.) · 2026Article
- Integrative single-cell RNA and ATAC sequencing reveals the impact of chronic cigarette smoking on lung epithelial responses to influenza and hyperoxia.Respiratory research · 2025Article
121 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To determine TRALI incidence by prospective, active surveillance and to identify risk factors by a case-control study, 2 academic medical centers enrolled 89 cases and 164 transfused controls. Recipient risk factors identified by multivariate analysis were higher IL-8 levels, liver surgery, chronic alcohol abuse, shock, higher peak airway pressure while being mechanically ventilated, current smoking, and positive fluid balance. Transfusion risk factors were receipt of plasma or whole blood from female donors (odds ratio = 4.5, 95% confidence interval [CI], 1.85-11.2, P = .001), volume of HLA class II antibody with normalized background ratio more than 27.5 (OR = 1.92/100 mL, 95% CI, 1.08-3.4, P = .03), and volume of anti-human neutrophil antigen positive by granulocyte immunofluoresence test (OR = 1.71/100 mL, 95% CI, 1.18-2.5, P = .004). Little or no risk was associated with older red blood cell units, noncognate or weak cognate class II antibody, or class I antibody. Reduced transfusion of plasma from female donors was concurrent with reduced TRALI incidence: 2.57 (95% CI, 1.72-3.86) in 2006 versus 0.81 (95% CI, 0.44-1.49) in 2009 per 10 000 transfused units (P = .002). The identified risk factors provide potential targets for reducing residual TRALI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.