ArticleHuman reproduction (Oxford, England)2012
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.
Article in Human reproduction (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.Human reproduction (Oxford, England) · 2022Pooled it
- Cracking the fertility code: a comprehensive review of biomarkers and functional measures.Open biology · 2026Review
- Association of Ethnicity With Ovarian Reserve: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- E-cigarette use (vaping) and cigarette smoking are associated with reduced markers of ovarian reserve: a cross-sectional study of 16,087 women.BMC women's health · 2026Article
- Comparative analysis of serum anti-Müllerian hormone (AMH) levels in sheep: the role of genetic background and physiological status.Archives animal breeding · 2026Article
- Role of inflammatory blood parameters from complete blood count in predicting ovarian follicular density in cancer patients undergoing ovarian tissue cryopreservation.Journal of ovarian research · 2025Observational
- miR-361-5p regulates SLC25A24 to maintain mitochondrial function and alleviate granulosa cell dysfunction in diminished ovarian reserve.Journal of assisted reproduction and genetics · 2025Article
- Gut microbiota: emerging biomarkers and potential therapeutics for premature ovarian failure.Frontiers in microbiology · 2025Review
- Using rare genetic mutations to revisit structural brain asymmetry.Nature communications · 2024Article
- Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles.Journal of assisted reproduction and genetics · 2024Article
- The gut microbiota: emerging biomarkers and potential treatments for infertility-related diseases.Frontiers in cellular and infection microbiology · 2024Review
- Antimüllerian Hormone as a Tool to Predict the Age at Menopause.Geriatrics (Basel, Switzerland) · 2023Article
- Reference Ranges of Serum Anti-Müllerian Hormone in Healthy Reproductive-aged Omani Women.Oman medical journal · 2023Article
- Determination of serum anti-Mullerian hormone levels in a low-prognosis women treated in-vitro fertilization/intracytoplasmic sperm injection: A cohort study.International journal of reproductive biomedicine · 2023Article
- Association between cigarette smoking and ovarian reserve among women seeking fertility care.PloS one · 2022Article
- Mechanisms of ovarian aging.Reproduction (Cambridge, England) · 2021Review
- Does the Anti-Mullerian Hormone Decline Rate Improve the Prediction of Age at Menopause?Frontiers in endocrinology · 2021Article
- Pregravid contraceptive use and fecundability: prospective cohort study.BMJ (Clinical research ed.) · 2020Article
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.medRxiv : the preprint server for health sciences · 2020Article
- Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function.The Journal of clinical endocrinology and metabolism · 2020Review
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe ovarian reserve (number and quality of oocytes) is correlated with reproductive potential as well as somatic health, and is likely to have multiple genetic and environmental determinants. Several reproductive hormones are closely linked with the oocyte pool and thus can serve as surrogate markers of ovarian reserve. However, we know little about the underlying genes or genetic variants.
methodsWe analyzed genetic variants across the genome associated with two hormonal markers of ovarian reserve, FSH and anti-Mullerian hormone, in a reproductively normal population of Caucasian (n = 232) and African American (n = 200) women, aged 25-45 years. We also examined the effects of environmental or lifestyle factors on ovarian reserve phenotypes.
resultsWe identified one variant approaching genome-wide significance (rs6543833; P= 8.07 × 10⁻⁸) and several nominal variants nearby and within the myeloid-associated differentiation marker-like (MYADML) gene, that were associated with FSH levels in African American women; these were validated in Caucasian women. We also discovered effects of smoking and oral contraceptive use on ovarian reserve phenotypes, with alterations in several reproductive hormones.
conclusionsThis work is the largest study on ovarian reserve in women of reproductive age and is the only genome-wide study on ovarian reserve markers. The genes containing or near the identified variants have no known roles in ovarian biology and represent interesting candidate genes for future investigations. The discovery of genetic markers may lead to better long-range predictions of declining ovarian function, with implications for reproductive and somatic health.
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