ArticleScience (New York, N.Y.)2011
Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.
Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- An optimized method for directed differentiation of hypothalamic neural stem cells in a 3D culture system.Scientific reports · 2025Article
- Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.Cellular & molecular biology letters · 2024Article
- CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity.Acta neuropathologica communications · 2023Article
- Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation.Communications biology · 2023Article
- A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus.Nutrients · 2022Article
- An Efficient Method for the Isolation and Cultivation of Hypothalamic Neural Stem/Progenitor Cells From Mouse Embryos.Frontiers in neuroanatomy · 2022Article
- A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy.CNS neuroscience & therapeutics · 2021Article
- Adult Neurogenesis and the Promise of Adult Neural Stem Cells.Journal of experimental neuroscience · 2019Review
- Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation.Nature neuroscience · 2018Article
- The Role of Lipid Metabolism for Neural Stem Cell Regulation.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- FGF1 - a new weapon to control type 2 diabetes mellitus.Nature reviews. Endocrinology · 2017Review
- POMC Neurons: From Birth to Death.Annual review of physiology · 2017Review
- Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain.PloS one · 2017Article
- Neural Substrate Expansion for the Restoration of Brain Function.Frontiers in systems neuroscience · 2016Review
- Article
- Review
- Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.Development (Cambridge, England) · 2015Article
- Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity.Physiological reviews · 2015Review
- The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Evolutionarily old and conserved homeostatic systems in the brain, including the hypothalamus, are organized into nuclear structures of heterogeneous and diverse neuron populations. To investigate whether such circuits can be functionally reconstituted by synaptic integration of similarly diverse populations of neurons, we generated physically chimeric hypothalami by microtransplanting small numbers of embryonic enhanced green fluorescent protein-expressing, leptin-responsive hypothalamic cells into hypothalami of postnatal leptin receptor-deficient (db/db) mice that develop morbid obesity. Donor neurons differentiated and integrated as four distinct hypothalamic neuron subtypes, formed functional excitatory and inhibitory synapses, partially restored leptin responsiveness, and ameliorated hyperglycemia and obesity in db/db mice. These experiments serve as a proof of concept that transplanted neurons can functionally reconstitute complex neuronal circuitry in the mammalian brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.