ArticleMedical oncology (Northwood, London, England)2012
Girdin protein: a new potential distant metastasis predictor of breast cancer.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating (GBA) motif.The Journal of biological chemistry · 2024Review
- Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer.Experimental and therapeutic medicine · 2018Article
- Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin.Cellular and molecular bioengineering · 2018Article
- The Gαi-GIV binding interface is a druggable protein-protein interaction.Scientific reports · 2017Article
- Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.The Journal of biological chemistry · 2016Article
- Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Constitutive activation of STAT3 in breast cancer cells: A review.International journal of cancer · 2016Review
- GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.The Journal of biological chemistry · 2016Article
- Girdin expression in cervical carcinoma and its role in the malignant properties of HeLa cells.Oncology letters · 2016Article
- Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer.Scientific reports · 2015Article
- Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.The Journal of cell biology · 2015Article
- Review
- GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.The Journal of biological chemistry · 2015Review
- Expression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion.International journal of clinical and experimental pathology · 2015Article
- Expression and clinical significance of girdin in gastric cancer.Molecular and clinical oncology · 2014Article
- Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad.Molecular pharmacology · 2014Review
- Clinical significance of Girdin expression detected by immunohistochemistry in non-small cell lung cancer.Oncology letters · 2014Article
- Clinical implications of Girdin and PI3K protein expression in breast cancer.Oncology letters · 2013Article
- STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis.The Journal of biological chemistry · 2012Article
- Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the expression status and the clinical implications of Girdin protein in breast cancer. The expression status of Girdin protein and clinicopathological parameters in 820 breast cancer specimens was analyzed using immunohistochemistry staining and the relationship between Girdin protein and clinicopathological parameters. The prognosis of breast cancer was subsequently determined. Girdin protein was expressed positively in 295 (35.98%) of the 820 cases examined. The expression of Girdin protein was related to histological type and CerbB2 (P = 0.001, 0.006, and 0.001, respectively). After analyzing survival rates, the cases with highly expressed Girdin protein were shown to attain a significantly more distant metastasis rate and poorer postoperative, disease-specific survival than those with none or low expressed Girdin protein (P = 0.001). In the Cox regression test, Girdin protein was detected as an independent prognostic factor (P = 0.031). Girdin protein may be a potential new distant metastasis biomarker of breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.