ArticleMedical oncology (Northwood, London, England)2012
Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dynamic kernel generation through hybrid involution and convolution neural networks for leukemia and white blood cell classification.Scientific reports · 2025Article
- Article
- Identification of clinically important chromosomal aberrations in acute myeloid leukemia by array-based comparative genomic hybridization.Leukemia & lymphoma · 2014Article
- Single-nucleotide polymorphism-array improves detection rate of genomic alterations in core-binding factor leukemia.Medical oncology (Northwood, London, England) · 2013Article
- Identifying the similarities and differences between single nucleotide polymorphism array (SNPa) analysis and karyotyping in acute myeloid leukemia and myelodysplastic syndromes.Revista brasileira de hematologia e hemoterapiaArticle
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Authors and funding
4 authors.
Funding
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Abstract
Improved outcome of acute myeloid leukemia (AML) depends on the better differentiation of subtypes to predict treatment response and the identification of new target for treatment. In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis.
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