ArticlePlant molecular biology2012
The Arabidopsis calmodulin-like proteins AtCML30 and AtCML3 are targeted to mitochondria and peroxisomes, respectively.
Article in Plant molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- A rice calmodulin-like protein OsCML27 participates in drought tolerance by fine-tuning OsRbohB-mediated ROS signaling.Science advances · 2026Article
- OsCML17 a pollen-expressed calmodulin-like protein regulates pollen germination and tube growth in rice (Oryza sativa).Plant cell reports · 2026Article
- Principles of signal integration in combinatorial stress acclimatization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Decrypting Molecular Mechanisms Involved in Counteracting Copper and Nickel Toxicity in Jack Pine (Plants (Basel, Switzerland) · 2024Article
- Genome-wide analysis of the CML gene family and its response to melatonin in common bean (Phaseolus vulgaris L.).Scientific reports · 2023Article
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2022Article
- Review
- Transport, functions, and interaction of calcium and manganese in plant organellar compartments.Plant physiology · 2021Review
- Molecular Evolution of Calcium Signaling and Transport in Plant Adaptation to Abiotic Stress.International journal of molecular sciences · 2021Review
- Genome-wide survey of the bHLH super gene family in Brassica napus.BMC plant biology · 2020Article
- Chloroplast Calcium Signaling in the Spotlight.Frontiers in plant science · 2020Review
- Article
- Pharmacological Strategies for Manipulating Plant CaInternational journal of molecular sciences · 2018Review
- Towards Understanding Plant Calcium Signaling through Calmodulin-Like Proteins: A Biochemical and Structural Perspective.International journal of molecular sciences · 2018Review
- A Glycine-Rich RNA-Binding Protein, CsGR-RBP3, Is Involved in Defense Responses Against Cold Stress in Harvested Cucumber (Frontiers in plant science · 2018Article
- Article
- Genome-Wide Identification and Analyses of Calmodulins and Calmodulin-like Proteins inFrontiers in plant science · 2017Article
- Plant peroxisomes: recent discoveries in functional complexity, organelle homeostasis, and morphological dynamics.Current opinion in plant biology · 2016Review
- CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence.Scientific reports · 2016Article
- The calmodulin-like proteins AtCML4 and AtCML5 are single-pass membrane proteins targeted to the endomembrane system by an N-terminal signal anchor sequence.Journal of experimental botany · 2016Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calmodulin (CaM) is a ubiquitous sensor/transducer of calcium signals in eukaryotic organisms. While CaM mediated calcium regulation of cytosolic processes is well established, there is growing evidence for the inclusion of organelles such as chloroplasts, mitochondria and peroxisomes into the calcium/calmodulin regulation network. A number of CaM-binding proteins have been identified in these organelles and processes such as protein import into chloroplasts and mitochondria have been shown to be governed by CaM regulation. What have been missing to date are the mediators of this regulation since no CaM or calmodulin-like protein (CML) has been identified in any of these organelles. Here we show that two Arabidopsis CMLs, AtCML3 and AtCML30, are localized in peroxisomes and mitochondria, respectively. AtCML3 is targeted via an unusual C-terminal PTS1-like tripeptide while AtCML30 utilizes an N-terminal, non-cleavable transit peptide. Both proteins possess the typical structure of CaMs, with two pairs of EF-hand motifs separated by a short linker domain. They furthermore display common characteristics, such as calcium-dependent alteration of gel mobility and calcium-dependent exposure of a hydrophobic surface. This indicates that they can function in a similar manner as canonical CaMs. The presence of close homologues to AtCML3 and AtCML30 in other plants further indicates that organellar targeting of these CMLs is not a specific feature of Arabidopsis. The identification of peroxisomal and mitochondrial CMLs is an important step in the understanding how these organelles are integrated into the cellular calcium/calmodulin signaling pathways.
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