ArticleCurrent infectious disease reports2012
Molecular diagnosis of diarrhea: current status and future potential.
Article in Current infectious disease reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults.The American journal of gastroenterology · 2016Guideline
- Diversity and Functional Predictions of Gut Microbiota in Vietnamese Children Aged 6-24 Months with Persistent Diarrhea of Unknown Etiology.Pathogens (Basel, Switzerland) · 2025Article
- Why are so many enteric pathogen infections asymptomatic? Pathogen and gut microbiome characteristics associated with diarrhea symptoms and carriage of diarrheagenicGut microbes · 2023Article
- Molecular Characterization of Hetero-Pathogenic and DiarrheagenicPathogens (Basel, Switzerland) · 2023Article
- Article
- Development of a proof-of-concept microfluidic portable pathogen analysis system for water quality monitoring.The Science of the total environment · 2022Article
- Evaluation of the BioFire Gastrointestinal Panel to Detect Diarrheal Pathogens in Pediatric Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Monitoring of diverse enteric pathogens across environmental and host reservoirs with TaqMan array cards and standard qPCR: a methodological comparison study.The Lancet. Planetary health · 2021Article
- Identification of Enteropathogens by Multiplex PCR among Rural and Urban Guatemalan Children with Acute Diarrhea.The American journal of tropical medicine and hygiene · 2019Article
- Epidemiological and clinical differences between sexes and pathogens in a three-year surveillance of acute infectious gastroenteritis in Shanghai.Scientific reports · 2019Article
- Detection of different enteric viruses in children with diarrheal disease: evidence of the high frequency of mixed infections.Access microbiology · 2019Article
- Whatman Protein Saver Cards for Storage and Detection of Parasitic Enteropathogens.The American journal of tropical medicine and hygiene · 2018Article
- Can clinical signs or symptoms combined with basic hematology data be used to predict the presence of bacterial infections in febrile children under - 5 years?BMC pediatrics · 2018Article
- Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years.JAMA pediatrics · 2018Article
- Travelers' Diarrhea in Thailand: A Quantitative Analysis Using TaqMan® Array Card.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai.Gut pathogens · 2018Article
- Detection of 23 Gastrointestinal Pathogens Among Children Who Present With Diarrhea.Journal of the Pediatric Infectious Diseases Society · 2017Article
- Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015.The Lancet. Infectious diseases · 2017Article
- FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea.BMC microbiology · 2017Article
- Aetiological characteristics of adult acute diarrhoea in a general hospital of Shanghai.Epidemiology and infection · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapidly changing research and practice in infectious diseases. Diarrheal disease, with its broad range of potential infectious etiologies, is well suited for multiplex molecular testing. This review highlights examples of currently employed molecular tests, as well as ways in which these tests can be applied in the future. The absence of a gold standard for the microbiologic cause of diarrhea means that the clinical significance of detected organisms may not always be clear. Conventional wisdom is that there should be one main pathogen causing diarrhea, however our thinking is challenged by increased detection of mixed infections. Thus, the successful incorporation of molecular diagnostics for diarrheal disease into practice will require both a careful understanding of the technical aspects and research to define their clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.