ArticleThe international journal of cardiovascular imaging2012
Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.
Article in The international journal of cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET.The international journal of cardiovascular imaging · 2014Article
- Advanced tracers in PET imaging of cardiovascular disease.BioMed research international · 2014Review
- Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction.EJNMMI research · 2013Article
- Positron emission tomography in the assessment of left ventricular function in healthy rats: a comparison of four imaging methods.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Cardiovascular imaging 2012 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2013Review
- Long-term survival after a massive left ventricular infarction evidenced by FDG-PET and leaving intact only the septal wall.International journal of clinical and experimental medicine · 2013Article
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Authors and funding
8 authors.
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Abstract
The rat myocardial infarction (MI) model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced (18)F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarct model. Nineteen Wistar rats had surgical occlusion of the left anterior descending coronary artery and 7 were sham-operated. PET was scheduled 48 h and 2 weeks later for quantifying MI area and LV function. Segments with <50% of FDG uptake had histological evidence of MI (74 ± 9% decrease in parietal thickness, fibrosis development). At 48 h, MI area was large (>35% of LV) in 6 rats, moderate (15-35% of LV) in 8 rats, limited (<15% of LV) in 5 rats and absent in the 7 sham rats. LV remodeling, assessed through the 2 weeks increase in end-diastolic volume, increased between rats with limited, moderate and large MI (+72 ± 25, +109 ± 56, +190 ± 69 μl, respectively, P = 0.007). This 3-groups classification allowed predicting 44% of the 2 weeks increase in end-diastolic volume, and additional 34% were predicted by heart rate at 48 h. The acipimox-enhanced FDG gated-PET technique provides efficient characterization and prediction of early remodeling in the rat infarct model.
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