ArticleEuropean journal of clinical pharmacology2012
The importance of drug-drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France.
Article in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The risk of hyponatremia induced by SSRIs and SNRIs antidepressants: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2025Pooled it
- The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Evaluating the risk of mild serotonin syndrome in primary care: a retrospective case series of patients with treatment-resistant depression.AME case reports · 2025Article
- Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016.Annals of general psychiatry · 2024Article
- Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels.European journal of clinical pharmacology · 2024Article
- Prevalence and sort of pharmacokinetic drug-drug interactions in hospitalized psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Spontaneous Reports of Serious Adverse Drug Reactions Resulting From Drug-Drug Interactions: An Analysis From the French Pharmacovigilance Database.Frontiers in pharmacology · 2020Article
- Identifying and Characterizing Serious Adverse Drug Reactions Associated With Drug-Drug Interactions in a Spontaneous Reporting Database.Frontiers in pharmacology · 2020Article
- Risk of Drug-Drug Interactions in Out-Hospital Drug Dispensings in France: Results From the DRUG-Drug Interaction Prevalence Study.Frontiers in pharmacology · 2019Article
- Detection of drug-drug interactions through data mining studies using clinical sources, scientific literature and social media.Briefings in bioinformatics · 2018Review
- Completeness of Spontaneous Adverse Drug Reaction Reports Sent by General Practitioners to a Regional Pharmacovigilance Centre: A Descriptive Study.Drug safety · 2016Article
- Polypharmacy and adverse outcomes after hip fracture surgery.Journal of orthopaedic surgery and research · 2016Article
- Hemorrhagic effects of oral anticoagulants: a comparative study between vitamin K antagonists (VKA) and direct oral anticoagulants (DOA).European journal of clinical pharmacology · 2015Article
- Atropinic burden of prescriptions forms in patients with Alzheimer disease: a cross-sectional study in a French PharmacoVigilance Database.European journal of clinical pharmacology · 2015Article
- Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) System.Toxicological research · 2015Review
- Systematic prediction of drug combinations based on clinical side-effects.Scientific reports · 2014Article
- Potentially inappropriate medications and adverse drug reactions in the elderly: a study in a PharmacoVigilance database.European journal of clinical pharmacology · 2014Article
- Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France.European journal of clinical pharmacology · 2013Article
- Data-driven prediction of drug effects and interactions.Science translational medicine · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database.
methodsAll spontaneous reports of ADRs registered in 2008 by the Midi-Pyrénées PharmacoVigilance Centre that contained mention of one of the serotoninergic reuptake inhibitor (SRI) antidepressants marketed in France were reviewed. DDIs were identified according to the French National Drug Formulary (Vidal) and the interaction supplement of the French independent drug bulletin La Revue Prescrire. ADRs explained by DDIs were characterised.
resultsAmong the 2,101 spontaneous reports recorded, 177 involved at least one SRI antidepressant. Among the 156 ADRs with at least one theoretical DDI, 41% (95% confidence interval 34-49%) could be explained by a DDI. The most frequent antidepressant involved in DDIs was escitalopram, followed by fluoxetine and citalopram. Among the 65 ADRs related to DDIs, 37 (52.9%) were "serious", mainly bleedings, confusion and falls, hyponatremia and serotoninergic syndromes. The most frequent drug interactions occurred with psychotropics (antipsychotics, benzodiazepines, among others), followed by antithrombotic agents (antagonists of vitamin K, antiplatelets), diuretics and angiotensin II antagonists. The group with ADRs related to DDIs was older than the group with ADRs not related to DDIs. ADRs were threefold more "serious" in the case of DDIs.
conclusionAround 40% of ADRs reported with SRIs were related to DDIs. Most of these occurred after association with psychotropics, antithrombotics, or diuretics, especially in the elderly.
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