ArticleMolecular and cellular endocrinology2012
Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction.
Article in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- 20-hydroxyecdysone-mediated regulation of the ribosomal protein Cs40SRPS4 via CsE74A is essential for vitellogenesis in Chilo suppressalis.Insect science · 2026Article
- Identification of the core region responsible for the activity of CmVg promoter and its regulatory transcription factor BrC in Cnaphalocrocis medinalis (Lepidoptera: Pyralidae).Journal of insect science (Online) · 2026Article
- Isoform-resolved transcriptomics reveals stage-specific isoform switching and protein domain remodeling inTranscription · 2026Article
- Article
- Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp.PLoS pathogens · 2024Article
- Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti.PLoS genetics · 2024Article
- A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.Molecular biology and evolution · 2023Article
- The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme-induced peroxidase.PLoS pathogens · 2023Article
- Review
- Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquitoProceedings of the National Academy of Sciences of the United States of America · 2021Article
- 20-Hydroxyecdysone (20E) signaling as a promising target for the chemical control of malaria vectors.Parasites & vectors · 2021Review
- Involvement ofFrontiers in physiology · 2021Article
- Article
- HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction.Insect biochemistry and molecular biology · 2018Article
- Broad-complex Z3 contributes to the ecdysone-mediated transcriptional regulation of the vitellogenin gene in Bombus lantschouensis.PloS one · 2018Article
- The impact of metagenomic interplay on the mosquito redox homeostasis.Free radical biology & medicine · 2017Review
- Ironing out the Details: Exploring the Role of Iron and Heme in Blood-Sucking Arthropods.Frontiers in physiology · 2017Review
- 20-Hydroxyecdysone (20E) Primary Response Gene E75 Isoforms Mediate Steroidogenesis Autoregulation and Regulate Developmental Timing in Bombyx.The Journal of biological chemistry · 2016Article
- RNA sequencing to characterize transcriptional changes of sexual maturation and mating in the female oriental fruit fly Bactrocera dorsalis.BMC genomics · 2016Article
- A comparative analysis of reproductive biology of insect vectors of human disease.Current opinion in insect science · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mosquitoes are adapted to using vertebrate blood as a nutrient source to promote egg development and as a consequence serve as disease vectors. Blood-meal activated reproductive events in female mosquitoes are hormonally and nutritionally controlled with an insect steroid hormone 20-hydroxyecdysone (20E) playing a central role. The nuclear receptor E75 is an essential factor in the 20E genetic hierarchy, however functions of its three isoforms - E75A, E75B, and E75C - in mosquito reproduction are unclear. By means of specific RNA interference depletion of E75 isoforms, we identified their distinct roles in regulating the level and timing of expression of key genes involved in vitellogenesis in the fat body (an insect analog of vertebrate liver and adipose tissue) of the mosquito Aedes aegypti. Heme is required in a high level of expression of 20E-controlled genes in the fat body, and this heme action depends on E75. Thus, in mosquitoes, heme is an important signaling molecule, serving as a sensor of the availability of a protein meal for egg development. Disruption of this signaling pathway could be explored in the design of mosquito control approaches.
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