ArticleBMC genomics2011
Comparative genomics of the Type VI secretion systems of Pantoea and Erwinia species reveals the presence of putative effector islands that may be translocated by the VgrG and Hcp proteins.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 101 citations in OpenAlex.
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- Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales.Molecular plant pathology · 2026Review
- Comparative genomics ofMicrobial genomics · 2026Article
- Plasmids serve as vehicles and reservoirs of type VI secretion systems.ISME communications · 2026Article
- Genetic diversity, virulence factors and drug resistance ofJournal of veterinary research · 2025Article
- Genomic profiling and experimental validation of type VI secretion system-associated proteins in Klebsiella.PLoS genetics · 2025Article
- Comparative genomics-based insights intoApplied and environmental microbiology · 2025Article
- The CRISPR/Cas9-Mediated Knockout ofVeterinary sciences · 2025Article
- T6SS in plant pathogens: unique mechanisms in complex hosts.Infection and immunity · 2024Review
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- Complete Genome Sequence ofMicroorganisms · 2023Article
- Diverse Virulence Attributes ofInternational journal of molecular sciences · 2023Article
- Diversity of the type VI secretion systems in theMicrobial genomics · 2023Article
- Comparative genomics to examine the endophytic potential of Pantoea agglomerans DAPP-PG 734.BMC genomics · 2022Article
- Putative transcription antiterminator RfaH contributes to Erwinia amylovora virulence.Molecular plant pathology · 2022Article
- Beneficial Effect and Potential Risk ofPlants (Basel, Switzerland) · 2022Review
- An antibacterial T6SS in Pantoea agglomerans pv. betae delivers a lysozyme-like effector to antagonize competitors.Environmental microbiology · 2022Article
- Article
- Genome sequencing provides new insights on the distribution of Erwinia amylovora lineages in northern Italy.Environmental microbiology reports · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Type VI secretion apparatus is assembled by a conserved set of proteins encoded within a distinct locus. The putative effector proteins Hcp and VgrG are also encoded within these loci. We have identified numerous distinct Type VI secretion system (T6SS) loci in the genomes of several ecologically diverse Pantoea and Erwinia species and detected the presence of putative effector islands associated with the hcp and vgrG genes.
resultsBetween two and four T6SS loci occur among the Pantoea and Erwinia species. While two of the loci (T6SS-1 and T6SS-2) are well conserved among the various strains, the third (T6SS-3) locus is not universally distributed. Additional orthologous loci are present in Pantoea sp. aB-valens and Erwinia billingiae Eb661. Comparative analysis of the T6SS-1 and T6SS-3 loci showed non-conserved islands associated with the vgrG and hcp, and vgrG genes, respectively. These regions had a G+C content far lower than the conserved portions of the loci. Many of the proteins encoded within the hcp and vgrG islands carry conserved domains, which suggests they may serve as effector proteins for the T6SS. A number of the proteins also show homology to the C-terminal extensions of evolved VgrG proteins.
conclusionsExtensive diversity was observed in the number and content of the T6SS loci among the Pantoea and Erwinia species. Genomic islands could be observed within some of T6SS loci, which are associated with the hcp and vgrG proteins and carry putative effector domain proteins. We propose new hypotheses concerning a role for these islands in the acquisition of T6SS effectors and the development of novel evolved VgrG and Hcp proteins.
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