ReviewCanadian journal of gastroenterology = Journal canadien de gastroenterologie2011
Epidemiology and burden of chronic constipation.
Review in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride citrate in the treatment of constipation in China: a systematic review and meta-analysis.BMC gastroenterology · 2023Pooled it
- Effect of external therapies of traditional Chinese medicine on constipation in patients with CRF: A meta-analysis.PloS one · 2023Pooled it
- Effect of fruit intake on functional constipation: A systematic review and meta-analysis of randomized and crossover studies.Frontiers in nutrition · 2022Pooled it
- Chronic constipation: A review of literature.Medicine · 2018Pooled it
- Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation.Canadian journal of gastroenterology & hepatology · 2014Pooled it
- Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype.World journal of gastroenterology · 2025Trial
- Prebiotic Galacto-Oligosaccharides Impact Stool Frequency and Fecal Microbiota in Self-Reported Constipated Adults: A Randomized Clinical Trial.Nutrients · 2022Trial
- Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.PLoS biology · 2021Trial
- Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial.Journal of digestive diseases · 2019Trial
- Electroacupuncture for Women with Chronic Severe Functional Constipation: Subgroup Analysis of a Randomized Controlled Trial.BioMed research international · 2019Trial
- A poly-herbal blend (Herbagut®) on adults presenting with gastrointestinal complaints: a randomised, double-blind, placebo-controlled study.BMC complementary and alternative medicine · 2018Trial
- Constipation with bloating: a clinical approach to evaluation and management.Annals of medicine · 2026Review
- Economic evaluation of Hirschsprung disease testing strategies for children with medically-refractory chronic constipation: A cost-effectiveness analysis.Journal of pediatric surgery · 2026Article
- Sunflower-Derived Pectin Oligogalacturonides Promote Defecation in Mice.Foods (Basel, Switzerland) · 2026Article
- Short and long-term outcomes of anorectal biofeedback therapy in patients with functional defecation disorders: Efficacy and predictors of response.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Joint association of sleep duration and physical activity with constipation: a cross-sectional study.Journal of global health · 2026Article
- Bali Chronic Constipation Roundtable Report: Chronic Constipation Management in Asia.Journal of neurogastroenterology and motility · 2026Article
- Multi-kingdom metagenomic characterization of the gut bacteriome, mycobiome, and virome in chronic functional constipation.Frontiers in cellular and infection microbiology · 2026Article
- Factor analysis of defecation status in the general elderly population: the Yamagata Cohort Study.Environmental health and preventive medicine · 2026Article
- Inverse association of alcohol consumption patterns with constipation and diarrhea: a population-based cross-sectional study.BMC gastroenterology · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic constipation is an important component of clinical gastroenterology practice worldwide. Based on the definition, either self-reported or using Rome criteria, chronic constipation can affect from 2% to 27% of the population. Constipation is physically and mentally troublesome for many patients, and can significantly interfere with their daily living and well-being. Although only a proportion of patients with constipation seek medical care, most of them use prescribed or over-the-counter medication to improve their condition. The health care costs of constipation are significant as evidenced by the hundreds of million dollars spent yearly on laxatives alone. Because constipation is more common in older patients and life expectancy is increasing, an increase in the prevalence of constipation is expected in the years to come, with the associated impact on quality of life and socioeconomic burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.