ArticlePloS one2011
Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Foliar application of nanoboron fertilizer at different growth stages enhanced the nutrient use efficiency of cauliflower, leading to improve productivity, quality, and profitability.BMC plant biology · 2026Article
- Deciphering the Boron Toxicity Tolerance Mechanisms ofLife (Basel, Switzerland) · 2026Article
- Genome-Wide Screens Identify Genes Responsible for Intrinsic Boric Acid Resistance in Escherichia coli.Biological trace element research · 2024Article
- Bayesian inference of sample-specific coexpression networks.Genome research · 2024Article
- Bayesian Optimized sample-specific Networks Obtained By Omics data (BONOBO).bioRxiv : the preprint server for biology · 2023Article
- Article
- Transcriptome Profiling of Duodenum Reveals the Importance of Boron Supplementation in Modulating Immune Activities in Rats.Biological trace element research · 2022Article
- A systematic genome-wide account of binding sites for the model transcription factor Gcn4.Genome research · 2022Article
- Ion Release From Prototype Surface Pre-Reacted Glass Ionomer (S-PRG) Sealer and EndoSequence BC Sealer.European endodontic journal · 2021Article
- Biolog Phenotype Microarray Is a Tool for the Identification of Multidrug Resistance Efflux Pump Inducers.Antimicrobial agents and chemotherapy · 2018Article
- Adjusting Boron Transport by Two-Step Tuning of Levels of the Efflux Transporter BOR1.Plant physiology · 2018Article
- Boron-Dependent Translational Suppression of the Borate ExporterPlant physiology · 2018Article
- Article
- Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.Biological trace element research · 2017Article
- The major facilitator superfamily transporter Knq1p modulates boron homeostasis in Kluyveromyces lactis.Folia microbiologica · 2016Article
- Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Article
- cDNA-AFLP analysis reveals the adaptive responses of citrus to long-term boron-toxicity.BMC plant biology · 2014Article
- Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability.Molecular systems biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified as a boron efflux pump whose expression is upregulated in response to boron treatment. Here, we found that the expression of ATR1 is associated with expression of genes involved in amino acid biosynthesis. These mechanisms are strictly controlled by the transcription factor Gcn4 in response to boron treatment. Further analyses have shown that boron impaired protein synthesis by promoting phosphorylation of eIF2α in a Gcn2 kinase dependent manner. The uncharged tRNA binding domain (HisRS) of Gcn2 is necessary for the phosphorylation of eIF2α in the presence of boron. We postulate that boron exerts its toxic effect through activation of the general amino acid control system and inhibition of protein synthesis. Since the general amino acid control pathway is conserved among eukaryotes, this mechanism of boron toxicity may be of general importance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.