ReviewDeutsches Arzteblatt international2011
Treatment strategies for resistant arterial hypertension.
Review in Deutsches Arzteblatt international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Renal Artery Denervation Combined with Pulmonary Vein Isolation in Patients with Heart Failure and Atrial Fibrillation: Pilot Study: Renal Artery Denervation in Treatment of Atrial Fibrillation and Heart Failure.Journal of clinical medicine · 2025Article
- Risk Factors for Various Cognitive Function Decline Trajectories in Adults Over 40 Years of Age: A Retrospective Cohort Study.Psychiatry investigation · 2023Article
- Exercise Hypertension in Athletes.Journal of clinical medicine · 2022Article
- Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction.Communications biology · 2022Article
- Effects and safety of Sacubitril/Valsartan (SV) on heart function and blood pressure in maintenance hemodialysis (MHD) patients.American journal of translational research · 2022Article
- Treatment resistant hypertension--investigation and conservative management.Deutsches Arzteblatt international · 2014Review
- Association of vitamin D status and blood pressure response after renal denervation.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Treating resistant hypertension: role of renal denervation.Integrated blood pressure control · 2013Review
- Article
- Improved heart rate dynamics in patients undergoing percutaneous renal denervation.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- A pseudo-quality assurance fig leaf.Deutsches Arzteblatt international · 2012Article
- An experimental procedure paid for by the general public.Deutsches Arzteblatt international · 2012Article
- Anxiety as an important factor.Deutsches Arzteblatt international · 2012Article
- A new procedure, but for whom?Deutsches Arzteblatt international · 2012Article
- Biased reasoning.Deutsches Arzteblatt international · 2012Article
- Stress: aspects of endocrine hypertension.Deutsches Arzteblatt international · 2012Article
- Major innovations and trends in the medical device sector.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2012Article
- Successful single-sided renal denervation approach in a patient with stenosis of an accessory renal artery.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResistant hypertension is defined as blood pressure above the target range set by current guidelines despite the concurrent use of three or more antihypertensive drugs of different classes, including a diuretic, at their maximum or highest tolerated doses. This problem affects 5% to 15% of all hypertensive patients and is thus commonly seen by both primary care physicians and specialists.
methodsReview of current guidelines and pertinent literature revealed by a selective Medline search.
resultsThe treatment of resistant hypertension is multimodal, involving systematic identification of secondary causes of hypertension as well as the exclusion of pseudoresistance (inadequate treatment). Non-pharmacological treatment includes weight loss, dietary salt restriction, exercise, and abstinence from alcohol. Drug treatment consists of an individualized combination of antihypertensive agents with different mechanisms of action. Activation of the sympathetic nervous system is considered to be a major element in the pathogenesis of resistant hypertension; a new interventional treatment, selective denervation of the renal sympathetic nerves, results in clinically relevant and sustained blood pressure reduction in ca. 84% of the patients undergoing the procedure (a mean decrease of office systolic blood pressure by 32 mm Hg and by 12 mm Hg at six months, p <0.001). Among the 206 patients who underwent this procedure in the setting of published studies, 5 had complications; these included pseudoaneurysm of the femoral artery and dissection of the renal artery during the introduction of the ablation catheter.
conclusionThe treatment of resistant hypertension is interdisciplinary and multimodal. The new and promising option of interventional renal sympathetic denervation can be considered for patients whose high blood pressure is inadequately controlled with medication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.