ArticleMolecular biology and evolution2012
Phylogenetic analysis and classification of the fungal bHLH domain.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- The Basic Helix-Loop-Helix Transcription Factors UvBhlh1 and UvBhlh6 Coordinate Virulence in the Rice False Smut Fungus Ustilaginoidea virens.Molecular plant pathology · 2026Article
- Comprehensive genomic identification and functional analysis ofChinese herbal medicines · 2026Article
- Properties of Putative APSES Transcription Factor AfpA inJournal of fungi (Basel, Switzerland) · 2025Article
- Identification of a Novel Metabolic Target for Bioactive Triterpenoids Biosynthesis inFrontiers in microbiology · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- The Significance of the Intrinsically Disordered Regions for the Functions of the bHLH Transcription Factors.International journal of molecular sciences · 2019Review
- Genome-wide identification, classification, and functional analysis of the basic helix-loop-helix transcription factors in the cattle, Bos Taurus.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene.The Journal of biological chemistry · 2016Article
- Article
- Genome-wide identification, classification and functional analyses of the bHLH transcription factor family in the pig, Sus scrofa.Molecular genetics and genomics : MGG · 2015Article
- Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development.Journal of proteome research · 2015Article
- Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris.Molecular genetics and genomics : MGG · 2015Article
- The Basic/Helix-Loop-Helix Protein Family in Gossypium: Reference Genes and Their Evolution during Tetraploidization.PloS one · 2015Article
- ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.PLoS pathogens · 2014Article
- A steroid receptor coactivator acts as the DNA-binding partner of the methoprene-tolerant protein in regulating juvenile hormone response genes.Molecular and cellular endocrinology · 2014Article
- Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.Molecular genetics and genomics : MGG · 2013Article
- Phylogeny, functional annotation, and protein interaction network analyses of the Xenopus tropicalis basic helix-loop-helix transcription factors.BioMed research international · 2013Article
- Accurate discrimination of bHLH domains in plants, animals, and fungi using biologically meaningful sites.BMC evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic Helix-Loop-Helix (bHLH) domain is an essential highly conserved DNA-binding domain found in many transcription factors in all eukaryotic organisms. The bHLH domain has been well studied in the Animal and Plant Kingdoms but has yet to be characterized within Fungi. Herein, we obtained and evaluated the phylogenetic relationship of 490 fungal-specific bHLH containing proteins from 55 whole genome projects composed of 49 Ascomycota and 6 Basidiomycota organisms. We identified 12 major groupings within Fungi (F1-F12); identifying conserved motifs and functions specific to each group. Several classification models were built to distinguish the 12 groups and elucidate the most discerning sites in the domain. Performance testing on these models, for correct group classification, resulted in a maximum sensitivity and specificity of 98.5% and 99.8%, respectively. We identified 12 highly discerning sites and incorporated those into a set of rules (simplified model) to classify sequences into the correct group. Conservation of amino acid sites and phylogenetic analyses established that like plant bHLH proteins, fungal bHLH-containing proteins are most closely related to animal Group B. The models used in these analyses were incorporated into a software package, the source code for which is available at www.fungalgenomics.ncsu.edu.
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