ReviewJournal of virology2012
Saffold virus, a novel human Cardiovirus with unknown pathogenicity.
Review in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Evidence of multiple bacterial, viral, and parasitic infectious disease agents inInfection ecology & epidemiology · 2025Article
- Comparison of viral communities in the blood, feces and various tissues of wild brown rats (Heliyon · 2023Article
- Structural diversity and biological role of the 5' untranslated regions of picornavirus.RNA biology · 2023Review
- Effects of Oxidative Stress on Protein Translation: Implications for Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- First Occurrence of Saffold Virus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2020Article
- Higher abundance of enterovirus A species in the gut of children with islet autoimmunity.Scientific reports · 2019Article
- Frequent detection of Saffold cardiovirus in adenoids.PloS one · 2019Article
- Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus.Viruses · 2018Article
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3.Journal of virology · 2016Article
- The Pathogenesis of Saffold Virus in AG129 Mice and the Effects of Its Truncated L Protein in the Central Nervous System.Viruses · 2016Article
- The Fecal Virome of Children with Hand, Foot, and Mouth Disease that Tested PCR Negative for Pathogenic Enteroviruses.PloS one · 2015Article
- Induction and suppression of innate antiviral responses by picornaviruses.Cytokine & growth factor reviews · 2014Review
- Saffold cardiovirus and multiple sclerosis: no evidence for an association.Annals of clinical and translational neurology · 2014Article
- Viral metagenomic analysis of feces of wild small carnivores.Virology journal · 2014Article
- The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.Journal of virology · 2014Article
- Picornavirus infection leading to immunosuppression.Future virology · 2014Article
- Theiler's murine encephalomyelitis virus as an experimental model system to study the mechanism of blood-brain barrier disruption.Journal of neurovirology · 2014Review
- Is there still room for novel viral pathogens in pediatric respiratory tract infections?PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although cardioviruses have been thought to mainly infect rodents, a novel human cardiovirus, designated Saffold virus (SAFV), was identified in 2007. SAFV is grouped with Theiler-like rat virus and Theiler's murine encephalomyelitis virus (TMEV) in the species Theilovirus of the genus Cardiovirus of the family Picornaviridae. Eight genotypes of SAFV have now been identified. SAFV has been isolated from nasal and stool specimens from infants presenting with respiratory and gastrointestinal symptoms as well as from children with nonpolio acute flaccid paralysis; however, the relationship of SAFV to this symptomatology remains unclear. Of note, the virus has also been isolated from the cerebrospinal fluid specimens of patients with aseptic meningitis. This finding is of interest since TMEV is known to cause a multiple sclerosis-like syndrome in mice. The involvement of SAFV in various diseases (e.g., respiratory illness, gastrointestinal illness, neurological diseases, and type I diabetes) is presently under investigation. In order to clarify the pathogenicity of SAFV, additional epidemiological studies are required. Furthermore, identification of the SAFV cellular receptor will help establish an animal model for SAFV infection and help clarify the pathogenesis of SAFV-related diseases. In addition, investigation of the tissue-specific expression of the receptor may facilitate development of a novel picornavirus vector, which could be a useful tool in gene therapy for humans. The study of viral factors involved in viral pathogenicity using a reverse genetics technique will also be important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.