ArticleJournal of virology2012
Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k/1b.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Epidemiology and Genotype Distribution of Hepatitis C Virus in Russia.Pathogens (Basel, Switzerland) · 2022Article
- DAA Treatment Failure in a HIV/HBV/HCV Co-Infected Patient Carrying a Chimeric HCV Genotype 4/1b.International journal of environmental research and public health · 2022Article
- Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America.Cell host & microbe · 2022Article
- Article
- Molecular detection and genomic characterization of diverse hepaciviruses in African rodents.Virus evolution · 2021Article
- Diverse HCV Strains And HIV URFS Identified Amongst People Who Inject Drugs In India.Scientific reports · 2020Article
- The ability of single genes vs full genomes to resolve time and space in outbreak analysis.BMC evolutionary biology · 2019Article
- Knock-on community impacts of a novel vector: spillover of emerging DWV-B from Varroa-infested honeybees to wild bumblebees.Ecology letters · 2019Article
- Hepatitis C virus genotype 1 and 2 recombinant genomes and the phylogeographic history of the 2k/1b lineage.Virus evolution · 2019Article
- Successful Hepatitis C Virus Eradication in a Hemodialysis Patient With 2k/1b Chimera Genotype: A Case Report and Literature Review.Gastroenterology research · 2019Article
- Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- First identification of a recombinant form of hepatitis C virus in Austrian patients by full-genome next generation sequencing.PloS one · 2017Article
- Next-Generation Sequencing: a Diagnostic One-Stop Shop for Hepatitis C?Journal of clinical microbiology · 2016Article
- Heads or Tails: Genotyping of Hepatitis C Virus Concerning the 2k/1b Circulating Recombinant Form.International journal of molecular sciences · 2016Article
- Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC.Scientific reports · 2016Article
- High incidence of the hepatitis C virus recombinant 2k/1b in Georgia: Recommendations for testing and treatment.Hepatology research : the official journal of the Japan Society of Hepatology · 2015Article
- Evolutionary and Phylogenetic Analysis of the Hepaciviruses and Pegiviruses.Genome biology and evolution · 2015Article
- Characterization of Hepatitis C Virus Recombination in Cameroon by Use of Nonspecific Next-Generation Sequencing.Journal of clinical microbiology · 2015Article
- Evidence that hepatitis C virus genome partly controls infection outcome.Evolutionary applications · 2014Article
- Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants.The Journal of infectious diseases · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Since its initial identification in St. Petersburg, Russia, the recombinant hepatitis C virus (HCV) 2k/1b has been isolated from several countries throughout Eurasia. The 2k/1b strain is the only recombinant HCV to have spread widely, raising questions about the epidemiological background in which it first appeared. In order to further understand the circumstances by which HCV recombinants might be formed and spread, we estimated the date of the recombination event that generated the 2k/1b strain using a Bayesian phylogenetic approach. Our study incorporates newly isolated 2k/1b strains from Amsterdam, The Netherlands, and has employed a hierarchical Bayesian framework to combine information from different genomic regions. We estimate that 2k/1b originated sometime between 1923 and 1956, substantially before the first detection of the strain in 1999. The timescale and the geographic spread of 2k/1b suggest that it originated in the former Soviet Union at about the time that the world's first centralized national blood transfusion and storage service was being established. We also reconstructed the epidemic history of 2k/1b using coalescent theory-based methods, matching patterns previously reported for other epidemic HCV subtypes. This study demonstrates the practicality of jointly estimating dates of recombination from flanking regions of the breakpoint and further illustrates that rare genetic-exchange events can be particularly informative about the underlying epidemiological processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.