ArticleJournal of virology2012
The role of evolutionary intermediates in the host adaptation of canine parvovirus.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 63 citations in OpenAlex.
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- Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Detection and molecular epidemiology of canine parvovirus and identification of highly pathogenic CPV-2c isolates from Shandong, China.Virus genes · 2025Article
- Evolutionary Dynamics and Pathogenicity Analysis of Feline Panleukopenia Virus in Xinjiang, China.Microorganisms · 2024Article
- Molecular Characterization of Feline Parvovirus from Domestic Cats in Henan Province, China from 2020 to 2022.Veterinary sciences · 2024Article
- Investigation of canine parvovirus occurrence in cats with clinical signs of feline panleukopenia in Slovakia - pilot study.Journal of veterinary research · 2024Article
- Complete genome sequence and phylogenetic analysis of feline panleukopenia virus from India.Virusdisease · 2024Article
- Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus.Communications biology · 2023Article
- Isolation of feline panleukopenia virus from Yanji of China and molecular epidemiology from 2021 to 2022.Journal of veterinary science · 2023Article
- Molecular characterization and genetic diversity of parvoviruses prevalent in cats in Central and Eastern China from 2018 to 2022.Frontiers in veterinary science · 2023Article
- Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential.Frontiers in immunology · 2023Article
- Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand.Pathogens (Basel, Switzerland) · 2022Article
- Predominance and first complete genomic characterization of canine parvovirus 2b in Turkey.Archives of virology · 2022Article
- Isolation and Genetic Characterization of Parvoviruses From Dogs, Cats, Minks, and Raccoon Dogs in the Eastern Region of Shandong Province, China.Frontiers in microbiology · 2022Article
- Article
- High-resolution asymmetric structure of a Fab-virus complex reveals overlap with the receptor binding site.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Molecular Epidemiological Survey of Canine Parvovirus Circulating in China from 2014 to 2019.Pathogens (Basel, Switzerland) · 2021Article
- Isolation and Genetic Characterization of Canine Parvovirus in a Malayan Tiger.Frontiers in veterinary science · 2021Article
- Parvovirus-induced encephalitis in a juvenile raccoon.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The adaptation of viruses to new hosts is a poorly understood process likely involving a variety of viral structures and functions that allow efficient replication and spread. Canine parvovirus (CPV) emerged in the late 1970s as a host-range variant of a virus related to feline panleukopenia virus (FPV). Within a few years of its emergence in dogs, there was a worldwide replacement of the initial virus strain (CPV type 2) by a variant (CPV type 2a) characterized by four amino acid differences in the capsid protein. However, the evolutionary processes that underlie the acquisition of these four mutations, as well as their effects on viral fitness, both singly and in combination, are still uncertain. Using a comprehensive experimental analysis of multiple intermediate mutational combinations, we show that these four capsid mutations act in concert to alter antigenicity, cell receptor binding, and relative in vitro growth in feline cells. Hence, host adaptation involved complex interactions among both surface-exposed and buried capsid mutations that together altered cell infection and immune escape properties of the viruses. Notably, most intermediate viral genotypes containing different combinations of the four key amino acids possessed markedly lower fitness than the wild-type viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.