ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Hydrodynamic cellular volume changes enable glioma cell invasion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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Who cites it
92 citing papers in PubMed, 139 citations in OpenAlex.
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- Toward functional precision oncology: organotypic brain slices in glioblastoma.Frontiers in oncology · 2026Review
- Piezo1 is an essential player in volume regulation of human glioblastoma cells.The Journal of physiology · 2025Article
- Variations among glioblastoma cell lines in boron-mediated enhancement of cell killing by proton beams.Scientific reports · 2025Article
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- Piezo1-related physiological and pathological processes in glioblastoma.Frontiers in cell and developmental biology · 2025Review
- Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation.Cell reports · 2024Article
- On-chip fabrication of tailored 3D hydrogel scaffolds to model cancer cell invasion and interaction with endothelial cells.APL bioengineering · 2024Article
- Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids.APL bioengineering · 2024Article
- Emerging Lipid Targets in Glioblastoma.Cancers · 2024Review
- Hypoxia, Ion Channels and Glioblastoma Malignancy.Biomolecules · 2023Review
- SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces.Molecular biology of the cell · 2023Article
- Compression drives diverse transcriptomic and phenotypic adaptations in melanoma.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications.Membranes · 2023Review
- Eukaryotic CRFK Cells Motion Characterized with Atomic Force Microscopy.International journal of molecular sciences · 2022Article
- Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges.Reviews of physiology, biochemistry and pharmacology · 2022Review
- Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain.ACS pharmacology & translational science · 2021Article
- Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in hereditary motor sensory neuropathy with agenesis of the corpus callosum.American journal of physiology. Cell physiology · 2021Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Malignant gliomas are highly invasive brain tumors that currently lack effective treatment. Unlike other cancers, gliomas do not metastasize via the vasculature but invade surrounding brain solely along extracellular routes, primarily moving along the vasculature and nerve tracts. This study uses several model systems to visualize and quantitatively assess cell volume changes of human glioma cells invading within the brain's extracellular space of C.B.17 severe combined immunodeficient (scid) mice and tumor cells invading in a modified Boyden chamber using three-dimensional multiphoton and confocal time-lapse microscopy. Regardless of model system used to quantitatively assess volume changes, invading glioma cells maximally decreased their volume by 30-35%, a value that was independent of barrier and cell size. Through osmotic challenges, we demonstrate that the observed cellular volume changes during invasion represent the smallest achievable cell volume and require glioma cells to release all free unbound cytoplasmic water. Water osmotically follows the release of Cl(-) through ion channels and cotransporters and blockade of Cl(-) flux inhibits both volume changes and cell invasion. Hence, invading glioma cells use hydrodynamic volume changes to meet the spatial constraints imposed within the brain, using essentially all free, unbound cytoplasmic water to maximally alter their volume as they invade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.