ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
- Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep.Communications biology · 2025Article
- Photoperiod-driven concurrent changes in hypothalamic and brainstem transcription of sleep and immune genes in migratory redheaded bunting.Proceedings. Biological sciences · 2023Article
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
- Phosphorylation Hypothesis of Sleep.Frontiers in psychology · 2020Review
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Activation of brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling in the pedunculopontine tegmental nucleus: a novel mechanism for the homeostatic regulation of rapid eye movement sleep.Journal of neurochemistry · 2017Article
- Role of calcium channels in bipolar disorder.Current psychopharmacology · 2017Article
- Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity.Frontiers in neural circuits · 2017Article
- The primate pedunculopontine nucleus region: towards a dual role in locomotion and waking state.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Implications of gamma band activity in the pedunculopontine nucleus.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Intracellular mechanisms modulating gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2016Article
- Pedunculopontine Gamma Band Activity and Development.Brain sciences · 2015Review
- High-threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2015Article
- The role of REM sleep theta activity in emotional memory.Frontiers in psychology · 2015Review
- Gamma band activity in the RAS-intracellular mechanisms.Experimental brain research · 2014Review
- Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.Frontiers in neurology · 2014Review
- About sleep's role in memory.Physiological reviews · 2013Review
- REM Sleep Regulating Mechanisms in the Cholinergic Cell Compartment of the Brainstem.Indian journal of sleep medicine · 2013Article
- The preconscious mind and gamma band activity in the reticular activating system.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The pedunculopontine tegmentum nucleus (PPT) is critically involved in the regulation of wakefulness (W) and rapid eye movement (REM) sleep, but our understanding of the mechanisms of this regulation remains incomplete. The present study was designed to determine the role of PPT intracellular calcium/calmodulin kinase (CaMKII) signaling in the regulation of W and sleep. To achieve this aim, three different concentrations (0.5, 1.0, and 2.0 nmol) of the CaMKII activation inhibitor, KN-93, were microinjected bilaterally (100 nl/site) into the PPT of freely moving rats, and the effects on W, slow-wave sleep (SWS), REM sleep, and levels of phosphorylated CaMKII (pCaMKII) expression in the PPT were quantified. These effects, which were concentration-dependent and affected wake-sleep variables for 3 h, resulted in decreased W, due to reductions in the number and duration of W episodes; increased SWS and REM sleep, due to increases in episode duration; and decreased levels of pCaMKII expression in the PPT. Regression analyses revealed that PPT levels of pCaMKII were positively related with the total percentage of time spent in W (R(2) = 0.864; n = 28 rats; p < 0.001) and negatively related with the total percentage of time spent in sleep (R(2) = 0.863; p < 0.001). These data provide the first direct evidence that activation of intracellular CaMKII signaling in the PPT promotes W and suppresses sleep. These findings are relevant for designing a drug that could treat excessive sleepiness by promoting alertness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.