ArticleProceedings of the National Academy of Sciences of the United States of America2012
Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 110 citations in OpenAlex.
- Viral influence on chemical communication in eusocial insects: insights and emerging research priorities.Journal of insect science (Online) · 2026Review
- A framework for identifying transcript orthologs: the evolution of sex bias in alternative transcript structure in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila.Nature communications · 2025Article
- Ultrastructure and Transcriptome Analysis of the Larval Integument in Solitary and Gregarious Phases ofInsects · 2025Article
- Is Drosophila Larval Competition Involved in Incipient Speciation?Journal of chemical ecology · 2025Article
- The genetic basis of incipient sexual isolation inProceedings. Biological sciences · 2024Article
- The genetic basis of variation iniScience · 2024Article
- Replenishment of Drosophila Male Pheromone After Mating.Journal of chemical ecology · 2024Article
- Genetic Coupling of Mate Recognition Systems in the Genomic Era.Cold Spring Harbor perspectives in biology · 2024Review
- Pathogen-Mediated Alterations of Insect Chemical Communication: From Pheromones to Behavior.Pathogens (Basel, Switzerland) · 2023Review
- Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.Science advances · 2023Article
- The population genetics of speciation by cascade reinforcement.Ecology and evolution · 2023Article
- Time series transcriptome analysis implicates the circadian clock in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A pleiotropic chemoreceptor facilitates the production and perception of mating pheromones.iScience · 2023Article
- Review
- Clock genes regulate mating activity rhythms in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus.PLoS neglected tropical diseases · 2022Article
- Aging-Related Variation of Cuticular Hydrocarbons in Wild Type and Variant Drosophila melanogaster.Journal of chemical ecology · 2022Article
- Male pheromones and their reception by females are co-adapted to affect mating success in two subspecies of brown rats.Current zoology · 2021Article
- A Tale of Two Transcriptomic Responses in Agricultural Pests via Host Defenses and Viral Replication.International journal of molecular sciences · 2021Article
- Clock genes and environmental cues coordinateScience (New York, N.Y.) · 2021Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals often use sex pheromones for mate choice and reproduction. As for other signals, the genetic control of the emission and perception of sex pheromones must be tightly coadapted, and yet we still have no worked-out example of how these two aspects interact. Most models suggest that emission and perception rely on separate genetic control. We have identified a Drosophila melanogaster gene, desat1, that is involved in both the emission and the perception of sex pheromones. To explore the mechanism whereby these two aspects of communication interact, we investigated the relationship between the molecular structure, tissue-specific expression, and pheromonal phenotypes of desat1. We characterized the five desat1 transcripts-all of which yielded the same desaturase protein-and constructed transgenes with the different desat1 putative regulatory regions. Each region was used to target reporter transgenes with either (i) the fluorescent GFP marker to reveal desat1 tissue expression, or (ii) the desat1 RNAi sequence to determine the effects of genetic down-regulation on pheromonal phenotypes. We found that desat1 is expressed in a variety of neural and nonneural tissues, most of which are involved in reproductive functions. Our results suggest that distinct desat1 putative regulatory regions independently drive the expression in nonneural and in neural cells, such that the emission and perception of sex pheromones are precisely coordinated in this species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.