ArticleClinical cancer research : an official journal of the American Association for Cancer Research2012
Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- A meta-analysis of MSI frequency and race in colorectal cancer.Oncotarget · 2016Pooled it
- Trial
- Novel recurrently mutated genes in African American colon cancers.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.Gastroenterology · 2015Trial
- Article
- Article
- Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.Genes · 2023Article
- Molecular genetics of early-onset colorectal cancer.World journal of biological chemistry · 2023Review
- Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Anatomic location of colorectal cancer presents a new paradigm for its prognosis in African American patients.PloS one · 2022Article
- Racial Disparities in Recurrence and Overall Survival in Patients With Locoregional Colorectal Cancer.Journal of the National Cancer Institute · 2021Article
- Racial/ethnic disparities in early-onset colorectal cancer: implications for a racial/ethnic-specific screening strategy.Cancer medicine · 2021Article
- Clinicopathological Significance ofJournal of Cancer · 2019Article
- Not all mutations ofInternational journal of clinical and experimental pathology · 2019Article
- Colorectal Cancer Disparity in African Americans: Risk Factors and Carcinogenic Mechanisms.The American journal of pathology · 2018Review
- Prognostic value of the combination of microsatellite instability andCancer management and research · 2018Article
- Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer.Clinical and translational gastroenterology · 2017Article
- Racial Disparities in Clinical Presentation and Survival Times Among Young-Onset Colorectal Adenocarcinoma.Digestive diseases and sciences · 2017Article
- The genetics and molecular biology of colonic neoplasia: practical implications for the clinician.Current opinion in gastroenterology · 2017Review
- Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease.Journal of cancer epidemiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeAfrican American colorectal cancer patients have worse survival outcomes than Caucasian patients. To determine whether differences exist in the molecular mechanisms driving colorectal cancer between African Americans and Caucasians, we characterized patient tumors from a single institution by assessing genetic alterations involved in colorectal cancer progression and response to treatment. EXPERIMENTAL
designWe retrospectively examined 448 African Americans and Caucasians diagnosed with colorectal cancer at The University of Chicago Medical Center between 1992 and 2002. Microsatellite instability (MSI) status was determined by genotyping the BAT25, BAT26, BAT40, D5S346, and BAX loci. Mutations in KRAS codons 12 and 13 and BRAF codon 600 were identified by direct sequencing. MSI and detected mutations were correlated with clinicopathologic features.
resultsOverall, no difference existed in MSI or BRAF mutation frequencies between African Americans and Caucasians. However, African Americans with microsatellite stable (MSS)/MSI-low (MSI-L) tumors had a higher proportion of KRAS mutations than Caucasians (34% vs. 23%, P = 0.048) that was isolated to proximal colon cancers and primarily driven by mutations in codon 13. There was no racial difference in receipt of chemotherapy, but African Americans with MSS/MSI-L tumors had a 73% increased risk of death over Caucasians that could not be explained by known prognostic factors.
conclusionsThe significantly higher risk of death among African Americans with MSS/MSI-L tumors may be related to differences in the distribution of factors influencing response to standard therapies. These data underscore the need for further research into the molecular mechanisms driving colorectal cancer progression in underserved and understudied populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.