Evidence map›Paper›PMID 22113923›Full record

ArticleAngewandte Chemie (International ed. in English)2012

Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.

Sarit S Agasti, Monty Liong, Carlos Tassa, Hyun Jung Chung, Stanley Y Shaw, Hakho Lee, Ralph Weissleder

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Dual imaging and photoactivated nanoprobe for controlled cell tracking.Small (Weinheim an der Bergstrasse, Germany) · 2013
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarit S AgastiCenter for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge St., Boston, MA 02114, USA.
Monty Liong
Carlos Tassa
Hyun Jung Chung
Stanley Y Shaw
Hakho Lee
Ralph Weissleder

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
StatisticsP50CA086355 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2015
$27.8M
The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
Novel Clickdyes for Biomedical SensingR01EB010011 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2010 to 2017
$3.1M
NCI NIH HHS P50 CA086355NCI NIH HHS T32 CA079443NCI NIH HHS U54 CA151884NHLBI NIH HHS HHSN268201000044CNIBIB NIH HHS R01-EB0044626NIBIB NIH HHS R01 EB004626NIBIB NIH HHS R01 EB010011NIBIB NIH HHS R01-EB010011NIDDK NIH HHS P30 DK043351PHS HHS P50A86355PHS HHS T32A79443PHS HHS U54A151884
6 · The paper itself

Abstract

Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.

Indexed as

AdamantaneAnimalsAntibodiesBiomarkersCell LineCyclodextrinsFluorescent DyesHumansNanoparticlesAdamantaneAntibodiesBiomarkersCyclodextrinsFluorescent Dyes

Identifiers

PMID22113923
PMCPMC3309171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.