ArticlePflugers Archiv : European journal of physiology2012
Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles.
Article in Pflugers Archiv : European journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The immediate effects of blood flow restriction training on upper limb muscle strength and fatigue level: a meta-analysis.Frontiers in physiology · 2025Pooled it
- Trial
- Skeletal Muscle Fibre Type Determines Mitochondrial and Metabolic Responses to Hypoxia and Pulmonary Inflammation in Young Adult Rats.Journal of cachexia, sarcopenia and muscle · 2026Article
- Plasticity and evolved changes in mitochondrial physiology across skeletal muscles of high-altitude deer mice (Peromyscus maniculatus).The Journal of experimental biology · 2026Article
- Review
- Chronic sustained hypoxia alters the pattern of diaphragm electrical activity in anaesthetized rats.Experimental physiology · 2025Article
- Diaphragm Dysfunction and Rehabilitation Strategy in Patients With Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2022Review
- Targeting the Mild-Hypoxia Driving Force for Metabolic and Muscle Transcriptional Reprogramming of Gilthead Sea Bream (Biology · 2021Article
- Mitochondrial respiration and HAmerican journal of physiology. Cell physiology · 2019Article
- Characterizing the influence of chronic hypobaric hypoxia on diaphragmatic myofilament contractile function and phosphorylation in high-altitude deer mice and low-altitude white-footed mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.PloS one · 2019Article
- Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine.Oxidative medicine and cellular longevity · 2018Article
- Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change.Oxidative medicine and cellular longevity · 2018Article
- Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.Frontiers in endocrinology · 2018Review
- Gene expression profiling of whole blood cells supports a more efficient mitochondrial respiration in hypoxia-challenged gilthead sea bream (Frontiers in zoology · 2017Article
- Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength.Hypoxia (Auckland, N.Z.) · 2017Review
- Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease.Physiological reports · 2016Article
- Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases.Frontiers in physiology · 2016Review
- Effects of Gestational and Postnatal Exposure to Chronic Intermittent Hypoxia on Diaphragm Muscle Contractile Function in the Rat.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal muscle adaptation to chronic hypoxia includes loss of oxidative capacity and decrease in fiber size. However, the diaphragm may adapt differently since its activity increases in response to hypoxia. Thus, we hypothesized that chronic hypoxia would not affect endurance, mitochondrial function, or fiber size in the mouse diaphragm. Adult male mice were kept in normoxia (control) or hypoxia (hypoxia, FIO(2) = 10%) for 4 weeks. After that time, muscles were collected for histological, biochemical, and functional analyses. Hypoxia soleus muscles fatigued faster (fatigue index higher in control, 21.5 ± 2.6% vs. 13.4 ± 2.4%, p < 0.05), but there was no difference between control and hypoxia diaphragm bundles. Mean fiber cross-sectional area was unchanged in hypoxia limb muscles, but it was 25% smaller in diaphragm (p < 0.001). Ratio of capillary length contact to fiber perimeter was significantly higher in hypoxia diaphragm (28.6 ± 1.2 vs. 49.3 ± 1.4, control and hypoxia, p < 0.001). Mitochondrial respiration rates in hypoxia limb muscles were lower: state 2 decreased 19%, state 3 31%, and state 4 18% vs. control, p < 0.05 for all comparisons. There were similar changes in hypoxia diaphragm: state 3 decreased 29% and state 4 17%, p < 0.05. After 4 weeks of hypoxia, limb muscle mitochondria had lower content of complex IV (cytochrome c oxidase), while diaphragm mitochondria had higher content of complexes IV and V (F (1)/F (0) ATP synthase) and less uncoupling protein 3 (UCP-3). These data demonstrate that diaphragm retains its endurance during chronic hypoxia, apparently due to a combination of morphometric changes and optimization of mitochondrial energy production.
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Registered trials
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