ArticleThe Journal of comparative neurology2012
In vivo time-lapse imaging of cell proliferation and differentiation in the optic tectum of Xenopus laevis tadpoles.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Ploidy and neuron size impact nervous system development and function in Xenopus.Cell reports · 2026Article
- Revisiting the critical roles of reactive microglia in traumatic brain injury.International journal of surgery (London, England) · 2025Review
- BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- A Focal Impact Model of Traumatic Brain Injury inInternational journal of molecular sciences · 2022Article
- Imaging Structural and Functional Dynamics inCold Spring Harbor protocols · 2022Article
- Proteomic screen reveals diverse protein transport between connected neurons in the visual system.Cell reports · 2022Article
- Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles.G3 (Bethesda, Md.) · 2022Article
- Thyroid hormone regulation of neural stem cell fate: From development to ageing.Acta physiologica (Oxford, England) · 2020Review
- A Simple and Efficient Method for Visualizing Individual CellsFrontiers in neural circuits · 2020Article
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.Journal of neurophysiology · 2019Article
- Article
- Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system.The Journal of experimental biology · 2017Article
- Mapping neurogenesis onset in the optic tectum of Xenopus laevis.Developmental neurobiology · 2016Article
- Thyroid Hormone Acts Locally to Increase Neurogenesis, Neuronal Differentiation, and Dendritic Arbor Elaboration in the Tadpole Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Long-term time-lapse live imaging reveals extensive cell migration during annelid regeneration.BMC developmental biology · 2016Article
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- Adult neural stem cell behavior underlying constitutive and restorative neurogenesis in zebrafish.Neurogenesis (Austin, Tex.) · 2016Article
- An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.Developmental biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We analyzed the function of neural progenitors in the developing central nervous system of Xenopus laevis tadpoles by using in vivo time-lapse confocal microscopy to collect images through the tectum at intervals of 2-24 hours over 3 days. Neural progenitor cells were labeled with fluorescent protein reporters based on expression of endogenous Sox2 transcription factor. With this construct, we identified Sox2-expressing cells as radial glia and as a component of the progenitor pool of cells in the developing tectum that gives rise to neurons and other radial glia. Lineage analysis of individual radial glia and their progeny demonstrated that less than 10% of radial glia undergo symmetric divisions resulting in two radial glia, whereas the majority of radial glia divide asymmetrically to generate neurons and radial glia. Time-lapse imaging revealed the direct differentiation of radial glia into neurons. Although radial glia may guide axons as they navigate to the superficial tectum, we find no evidence that radial glia function as a scaffold for neuronal migration at early stages of tectal development. Over 3 days, the number of labeled cells increased 20%, as the fraction of radial glia dropped and the proportion of neuronal progeny increased to approximately 60% of the labeled cells. Tadpoles provided with short-term visual enhancement generated significantly more neurons, with a corresponding decrease in cell proliferation. Together these results demonstrate that radial glial cells are neural progenitors in the developing optic tectum and reveal that visual experience increases the proportion of neurons generated in an intact animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.