ArticleArchives of microbiology2012
The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.
Article in Archives of microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- A Novel Secreted Cysteine-Rich Anionic (Sca) Protein from the Citrus Postharvest PathogenJournal of fungi (Basel, Switzerland) · 2020Article
- Oxidative stress and the presence of bacteria increase gene expression of the antimicrobial peptidePeerJ · 2019Article
- New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176.Scientific reports · 2018Article
- New fungal defensin-like peptides provide evidence for fold change of proteins in evolution.Bioscience reports · 2017Article
- Hitting the sweet spot-glycans as targets of fungal defense effector proteins.Molecules (Basel, Switzerland) · 2015Review
- The fungal defensin family enlarged.Pharmaceuticals (Basel, Switzerland) · 2014Review
- bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans.Microbiology (Reading, England) · 2013Article
- Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.PloS one · 2013Article
- Antifungal proteins: More than antimicrobials?Fungal biology reviews · 2013Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the genome of Aspergillus nidulans, a defensin-like protein, Anisin1, was annotated with high homology to the mosquito defensin AaDefA1. So far, no studies exist on defensins from filamentous ascomycetes. Therefore, we characterized the anisin1 gene in A. nidulans and generated a deletion mutant, which suffered from a defect in mitospore development and produced less conidia at 42°C compared to the reference strain. In surface cultures of A. nidulans wild type, the anisin1 expression correlated with that of the central regulator for asexual development, brlA, and with the major scavanger of H(2)O(2) stress, catB, which is indicative for cell differentiation in developing fungi. Interestingly, brlA and anisin1 expressions were deregulated in a ΔsrrA strain that covers a central role in the histidine-to-aspartate (His-Asp) phosphorelay signaling pathway and shows impaired asexual development and H(2)O(2) detoxification. In submers cultures of A. nidulans wild type and other mutants of the His-Asp phosphorelay signaling pathway, anisin1 was repressed, but derepressed in a ΔsrrA background, and anisin1 transcription was further increased in this mutant by H(2)O(2) addition. We therefore conclude that the secreted protein Anisin1 contributes to the optimal development of A. nidulans and we further propose that it has a sensing/signaling function for elevated H(2)O(2) levels.
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