Evidence map›Paper›PMID 22113000›Full record

ReviewCurrent opinion in pulmonary medicine2012

Microbes and asthma: the missing cellular and molecular links.

Tina Brar, Srinivas Nagaraj, Shyam Mohapatra

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in pulmonary medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. The respiratory microbiome and innate immunity in asthma.Current opinion in pulmonary medicine · 2015
    Review
  14. Review
  15. Corticosteroids in the treatment of acute asthma.Annals of thoracic medicine · 2014
    Review
  16. Article
  17. The microbiome of the lung.Translational research : the journal of laboratory and clinical medicine · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tina BrarDivision of Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA.
Srinivas Nagaraj
Shyam Mohapatra
Florida College · US

Funding

An Integrated Nano-Cell Delivery Platform of Theranostics for Lung CancersR01CA152005 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI MOHAPATRA, SHYAM S, MOHAPATRA, SUBHRA · 2010 to 2014
$1.4M
Nanomedicine Research Center Core (NRCC)P30HL101265 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI MOHAPATRA, SHYAM S · 2009 to 2010
$1.3M
Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic AsthmaR01HL071101 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI MOHAPATRA, SHYAM S · 2003 to 2006
$1.2M
NCI NIH HHS 1R01CA152005-01NCI NIH HHS R01 CA152005NHLBI NIH HHS 1P30HL101265NHLBI NIH HHS P30 HL101265NHLBI NIH HHS R01 HL071101
6 · The paper itself

Abstract

purpose of reviewIn this review, we describe the 'state-of-the-art' in our knowledge of asthma and what gaps exist, which can be exploited in the future for effective translation of our knowledge from the bench or population studies to diagnosis and therapy. RECENT

findingsThe advent of microbiome research has expanded the potential role of microbes in asthma. There has been a significant increase in our understanding of the pathologic, genetic, cellular and molecular mechanisms of asthma. Nonetheless, the contribution of microbes to the genesis, exacerbation and treatment of asthma are poorly understood. SUMMARY: Asthma is a complex chronic disease of the lung whose incidence is growing at all ages despite the progress that has been made in the areas of diagnosis and treatment of asthma. The complexity is partly due to the environmental insults such as allergens and microbial infections that play differential roles in the pathogenesis of childhood vis-à-vis elderly asthma. Microbes may play important roles in the exacerbation of asthma and hence in the comorbidities due to asthma, and also in the causation of asthma.

Indexed as

AgedAged, 80 and overAge FactorsAsthmaCD4-Positive T-LymphocytesChildChild, PreschoolCorynebacterium InfectionsFemaleHumansInfantInterleukin-1Interleukin-6MaleMetagenomeRespiratory Tract InfectionsInterleukin-1Interleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID22113000
PMCPMC3532043
OpenAlexW2043308150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.