SynthesisAIDS (London, England)2012
HIV infection and risk of overdose: a systematic review and meta-analysis.
Synthesis in AIDS (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03699020 (Acceptance and Commitment Therapy to Address the Psychosocial Co-Morbidities of Chronic Pain in Aging People Living With HIV), which is not on this map. Cited by 64 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acceptance and Commitment Therapy to Address the Psychosocial Co-Morbidities of Chronic Pain in Aging People Living With HIV
Who cites it
64 citing papers in PubMed, 6 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Economic Evaluations of Establishing Opioid Overdose Prevention Centers in 12 North American Cities: A Systematic Review.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2024Pooled it
- Psychosocial factors associated with overdose subsequent to Illicit Drug use: a systematic review and narrative synthesis.Harm reduction journal · 2024Pooled it
- A systematic review of the distribution of take-home naloxone in low- and middle-income countries and barriers to the implementation of take-home naloxone programs.Harm reduction journal · 2022Pooled it
- The Pre-exposure Prophylaxis (PrEP) Care Cascade in People Who Inject Drugs: A Systematic Review.AIDS and behavior · 2021Pooled it
- Socioeconomic marginalization and opioid-related overdose: A systematic review.Drug and alcohol dependence · 2020Pooled it
- Worldwide Prevalence and Trends in Unintentional Drug Overdose: A Systematic Review of the Literature.American journal of public health · 2015Pooled it
- Causes and risk factors of death among people who inject drugs in Indonesia, Ukraine and Vietnam: findings from HPTN 074 randomized trial.BMC infectious diseases · 2023Trial
- Trial
- Reducing opioid overdose in Kazakhstan: A randomized controlled trial of a couple-based integrated HIV/HCV and overdose prevention intervention "Renaissance".The International journal on drug policy · 2018Trial
- Differential long-term outcomes for voluntary and involuntary transition from injection to oral opioid maintenance treatment.Substance abuse treatment, prevention, and policy · 2014Trial
- Understanding barriers to healthcare and harm reduction services among women who inject drugs in Nigeria: A qualitative assessment.PLOS global public health · 2026Article
- Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study.Addictive behaviors reports · 2025Article
- Removing barriers to care: The importance of addressing nonfatal overdoses among women living with HIV in British Columbia, Canada.Canadian journal of public health = Revue canadienne de sante publique · 2025Article
- Rapid Assessment Amid an Injection Drug Use-Driven HIV Outbreak in Massachusetts' Merrimack Valley: Highlights from a Case Study.AIDS and behavior · 2025Article
- Correction: Rapid Assessment Amid an Injection Drug Use-Driven HIV Outbreak in Massachusetts' Merrimack Valley: Highlights from a Case Study.AIDS and behavior · 2025Article
- Cohort Profile Update: Reflecting back and looking ahead: Updating the Comparative Outcomes and Service Utilization Trends (COAST) Study to include 28 years of linked data from people with and without HIV in British Columbia, Canada.International journal of population data science · 2025Article
- Article
- "We only trust each other": A qualitative study exploring the overdose risk environment among persons who inject drugs living with HIV in Nairobi, Kenya.PLOS global public health · 2024Article
- A Diagram of the Social-Ecological Conditions of Opioid Misuse and Overdose.International journal of environmental research and public health · 2023Review
- Integrating long-acting injectable treatment to improve medication adherence among persons living with HIV and opioid use disorder: study protocol.Addiction science & clinical practice · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Drug overdose is a common cause of non-AIDS death among people with HIV and the leading cause of death for people who inject drugs. People with HIV are often exposed to opioid medications during their HIV care experience; others may continue to use illicit opioids despite their disease status. In either situation, there may be a heightened risk for nonfatal or fatal overdose. The potential mechanisms for this elevated risk remain controversial. We systematically reviewed the literature on the HIV-overdose association, meta-analyzed results, and investigated sources of heterogeneity, including study characteristics related to hypothesize biological, behavioral, and structural mechanisms of the association. Forty-six studies were reviewed, 24 of which measured HIV status serologically and provided data quantifying an association. Meta-analysis results showed that HIV seropositivity was associated with an increased risk of overdose mortality (pooled risk ratio 1.74, 95% confidence interval 1.45, 2.09), although the effect was heterogeneous (Q = 80.3, P < 0.01, I(2) = 71%). The wide variability in study designs and aims limited our ability to detect potentially important sources of heterogeneity. Causal mechanisms considered in the literature focused primarily on biological and behavioral factors, although evidence suggests structural or environmental factors may help explain the greater risk of overdose among HIV-infected drug users. Gaps in the literature for future research and prevention efforts as well as recommendations that follow from these findings are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.