ArticleJournal of biomedical optics2011
Tissue refractive index as marker of disease.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 272 citations in OpenAlex.
- Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Optical diffraction tomographic microscopy: a cutting-edge label-free three-dimensional bioimaging.Biophysics reports · 2026Article
- Depth-sensitive optical property characterization using multi-frequency laparoscopic spatial frequency domain imaging.Biomedical optics express · 2026Article
- Effect of fabrication error on the sensitivity of a one-dimensional photonic crystal sensor for cancer detection.Scientific reports · 2026Article
- Morphological and Optical Characterization of NRAS-Mutant Melanoma Cells and Primary Melanocytes via Quantitative Phase Imaging With Digital Holographic Microscopy.Cell biochemistry and function · 2026Article
- Advances in Label-Free Detection of Non-Muscle Invasive Bladder Cancer: A Critical Review.Bioengineering (Basel, Switzerland) · 2025Review
- Efficient, gigapixel-scale, aberration-free whole slide scanner using angular ptychographic imaging with closed-form solution.Biomedical optics express · 2024Article
- White Light Diffraction Phase Microscopy in Imaging of Breast and Colon Tissues.Diagnostics (Basel, Switzerland) · 2024Article
- Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage.Journal of biomedical optics · 2024Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Perspective on quantitative phase imaging to improve precision cancer medicine.Journal of biomedical optics · 2024Article
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.Journal of biomedical optics · 2024Review
- Article
- Multi-wavelength interference phase imaging for automatic breast cancer detection and delineation using diffuse reflection imaging.Scientific reports · 2024Article
- Random Lasing for Bimodal Imaging and Detection of Tumor.Biosensors · 2023Article
- Polarization differential interference contrast microscopy with physics-inspired plug-and-play denoiser for single-shot high-performance quantitative phase imaging.Biomedical optics express · 2023Article
- Influence of hematoxylin and eosin staining on linear birefringence measurement of fibrous tissue structures in polarization microscopy.Journal of biomedical optics · 2023Article
- Quantitative Phase Imaging Using Digital Holographic Microscopy to Assess the Degree of Intestinal Inflammation in Patients with Ulcerative Colitis.Journal of clinical medicine · 2023Article
- Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy.Nano letters · 2023Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The gold standard in histopathology relies on manual investigation of stained tissue biopsies. A sensitive and quantitative method for in situ tissue specimen inspection is highly desirable, as it would allow early disease diagnosis and automatic screening. Here we demonstrate that quantitative phase imaging of entire unstained biopsies has the potential to fulfill this requirement. Our data indicates that the refractive index distribution of histopathology slides, which contains information about the molecular scale organization of tissue, reveals prostate tumors and breast calcifications. These optical maps report on subtle, nanoscale morphological properties of tissues and cells that cannot be recovered by common stains, including hematoxylin and eosin. We found that cancer progression significantly alters the tissue organization, as exhibited by consistently higher refractive index variance in prostate tumors versus normal regions. Furthermore, using the quantitative phase information, we obtained the spatially resolved scattering mean free path and anisotropy factor g for entire biopsies and demonstrated their direct correlation with tumor presence. In essence, our results show that the tissue refractive index reports on the nanoscale tissue architecture and, in principle, can be used as an intrinsic marker for cancer diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.