ArticleBMC genomics2011
The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 65 citations in OpenAlex.
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- Refined Phylogenetic Ortholog Inference Reveals Coevolutionary Expansion of the MAPK Signaling Network Through Finetuning of Pathway Specificity.Journal of molecular evolution · 2025Article
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- The Intestinal Immune Defense System in Insects.International journal of molecular sciences · 2022Review
- The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes.Open biology · 2022Article
- Molecular Targets of Brown Algae Phlorotannins for the Therapy of Inflammatory Processes of Various Origins.Marine drugs · 2022Review
- Transcriptome Analysis of anInternational journal of molecular sciences · 2022Article
- The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host.PLoS pathogens · 2021Article
- Response Mechanisms of Invertebrates toMicrobiology and molecular biology reviews : MMBR · 2021Review
- The Ras/ERK signaling pathway couples antimicrobial peptides to mediate resistance to dengue virus in Aedes mosquitoes.PLoS neglected tropical diseases · 2020Article
- JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184.PLoS pathogens · 2020Article
- MAPK-directed activation of the whitefly transcription factorProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular mechanism by whichBioscience reports · 2018Article
- Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection.PLoS pathogens · 2018Article
- Opportunities for Host-targeted Therapies for Malaria.Trends in parasitology · 2018Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAnopheles gambiae is the primary mosquito vector of human malaria parasites in sub-Saharan Africa. To date, three innate immune signaling pathways, including the nuclear factor (NF)-kappaB-dependent Toll and immune deficient (IMD) pathways and the Janus kinase/signal transducers and activators of transcription (Jak-STAT) pathway, have been extensively characterized in An. gambiae. However, in addition to NF-kappaB-dependent signaling, three mitogen-activated protein kinase (MAPK) pathways regulated by JNK, ERK and p38 MAPK are critical mediators of innate immunity in other invertebrates and in mammals. Our understanding of the roles of the MAPK signaling cascades in anopheline innate immunity is limited, so identification of the encoded complement of these proteins, their upstream activators, and phosphorylation profiles in response to relevant immune signals was warranted.
resultsIn this study, we present the orthologs and phylogeny of 17 An. gambiae MAPKs, two of which were previously unknown and two others that were incompletely annotated. We also provide detailed temporal activation profiles for ERK, JNK, and p38 MAPK in An. gambiae cells in vitro to immune signals that are relevant to malaria parasite infection (human insulin, human transforming growth factor-beta1, hydrogen peroxide) and to bacterial lipopolysaccharide. These activation profiles and possible upstream regulatory pathways are interpreted in light of known MAPK signaling cascades.
conclusionsThe establishment of a MAPK "road map" based on the most advanced mosquito genome annotation can accelerate our understanding of host-pathogen interactions and broader physiology of An. gambiae and other mosquito species. Further, future efforts to develop predictive models of anopheline cell signaling responses, based on iterative construction and refinement of data-based and literature-based knowledge of the MAP kinase cascades and other networked pathways will facilitate identification of the "master signaling regulators" in biomedically important mosquito species.
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