ArticleAnalytical chemistry2012
CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography/mass spectrometry data sets.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 551 papers, 1 of them a synthesis that pooled it.
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Who cites it
551 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating LC-HRMS metabolomics data processing software using FAIR principles for research software.Metabolomics : Official journal of the Metabolomic Society · 2023Pooled it
- Impact of wheat aleurone on biomarkers of cardiovascular disease, gut microbiota and metabolites in adults with high body mass index: a double-blind, placebo-controlled, randomized clinical trial.European journal of nutrition · 2022Trial
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- Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz.Molecular systems biology · 2026Article
- Non-volatile metabolomic differentiation of geographical origin and quality grade in pre-Qingming Xihu Longjing green tea using in-source fragment ion-assisted annotation.Food chemistry: X · 2026Article
- Mass Spectrometry-Based Chromatographic and Computational Workflows for Biomarker and Therapeutic Target Discovery: A Comprehensive Review.Biomedical chromatography : BMC · 2026Review
- A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.Nature aging · 2026Article
- Organ-Resolved Untargeted LC-MS/MS Profiling of Putative Metabolite Families in Aerial Organs ofMetabolites · 2026Article
- Exome sequencing and metabolite profiling identifies genetic variants associated with altered metabolism in early-onset schizophrenia.iScience · 2026Article
- Distinct Lipid Compositions in Seawater and the Sea Surface Microlayer Measured with Liquid Chromatography and High-Resolution Mass Spectrometry.ACS earth & space chemistry · 2026Article
- Metabolic partitioning between photosynthesis and osmotrophy in Collodaria photosymbiotic holobionts.Nature communications · 2026Article
- Using MetaboAnalyst 6.0 for exposomics data analysis-from LC-MS2 spectra processing to dose-response modeling and causal inference.Nature protocols · 2026Review
- Low-Dose Intestinal Irradiation Enhances the Efficacy and Prognosis of PD-1 Blockade in Metastatic Non-Small Cell Lung Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Iron Chlorin e6 Improves Soybean Yield by Maintaining Chlorophyll Stability and Promoting Carbohydrate Accumulation Under Saline-Alkali Stress.Plants (Basel, Switzerland) · 2026Article
- LC-HRMS and Molecular Networking for Non-Targeted Screening of Emerging Contaminants in Cosmetics: Workflow, Applications, and Regulatory Challenges.Molecules (Basel, Switzerland) · 2026Review
- Cesarean section-induced changes in the gut microbiota facilitate metabolic disease in high-fat diet-induced obese mice.Microbiome · 2026Article
- Microbial single-cell transcriptomics links gut microbiota functional states to metabolic changes in male mice.Nature communications · 2026Article
- Donor-Independent Metabolomics Enables Bloodstain Age Determination at Crime Scenes.Journal of proteome research · 2026Article
- aiSysMet: AI-powered systems metabolomics for biomarker discovery.Bioinformatics (Oxford, England) · 2026Article
491 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Liquid chromatography coupled to mass spectrometry is routinely used for metabolomics experiments. In contrast to the fairly routine and automated data acquisition steps, subsequent compound annotation and identification require extensive manual analysis and thus form a major bottleneck in data interpretation. Here we present CAMERA, a Bioconductor package integrating algorithms to extract compound spectra, annotate isotope and adduct peaks, and propose the accurate compound mass even in highly complex data. To evaluate the algorithms, we compared the annotation of CAMERA against a manually defined annotation for a mixture of known compounds spiked into a complex matrix at different concentrations. CAMERA successfully extracted accurate masses for 89.7% and 90.3% of the annotatable compounds in positive and negative ion modes, respectively. Furthermore, we present a novel annotation approach that combines spectral information of data acquired in opposite ion modes to further improve the annotation rate. We demonstrate the utility of CAMERA in two different, easily adoptable plant metabolomics experiments, where the application of CAMERA drastically reduced the amount of manual analysis.
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