ArticlePain research and treatment2012
Early life adversity as a risk factor for fibromyalgia in later life.
Article in Pain research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Fibromyalgia in cancer patients: a systematic review and clinical implications for integrated care.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Pooled it
- Understanding fibromyalgia beyond pain: emotional imbalance and the case for compassionate care.RMD open · 2026Review
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Social Determinants and Consequences of Pain: Toward Multilevel, Intersectional, and Life Course Perspectives.The journal of pain · 2024Review
- Neuronutritional Approach to Fibromyalgia Management: A Narrative Review.Pain and therapy · 2024Review
- Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation.International journal of molecular sciences · 2023Review
- Early life factors associated with the experiences of pain in later life: evidence from a population based study in India.BMC public health · 2023Article
- Analysis of malingered psychological symptoms in a clinical sample for early detection in initial interviews.European archives of psychiatry and clinical neuroscience · 2023Article
- Fibromyalgia Pathophysiology.Biomedicines · 2022Review
- Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study.Pain research & management · 2022Observational
- Nociceptor Overexpression of NaThe journal of pain · 2021Article
- Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction: A Prospective Questionnaire Study.Mayo Clinic proceedings. Innovations, quality & outcomes · 2019Article
- Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People.Pain research & management · 2019Review
- Psychological impact of fibromyalgia: current perspectives.Psychology research and behavior management · 2019Review
- Subliminal emotional pictures are capable of modulating early cerebral responses to pain in fibromyalgia.PloS one · 2019Article
- Early life abuse and risk of endometriosis.Human reproduction (Oxford, England) · 2018Article
- Phenotypic Features of Central Sensitization.Journal of applied biobehavioral research · 2018Article
- Early Procedural Pain Is Associated with Regionally-Specific Alterations in Thalamic Development in Preterm Neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of early life events is increasingly becoming apparent, as studies investigate how early childhood can shape long-term physiology and behaviour. Fibromyalgia (FM), which is characterised by increased pain sensitivity and a number of affective co-morbidities, has an unclear etiology. This paper discusses risk factors from early life that may increase the occurrence or severity of FM in later life: pain experience during neonatal life causes long-lasting changes in nociceptive circuitry and increases pain sensitivity in the older organism; premature birth and related stressor exposure cause lasting changes in stress responsivity; maternal deprivation affects anxiety-like behaviours that may be partially mediated by epigenetic modulation of the genome-all these adult phenotypes are strikingly similar to symptoms displayed by FM sufferers. In addition, childhood trauma and exposure to substances of abuse may cause lasting changes in developing neurotransmitter and endocrine circuits that are linked to anxiety and stress responses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.