Evidence map›Paper›PMID 22110874›Full record

ArticleNano reviews2011

Engineering periplasmic ligand binding proteins as glucose nanosensors.

Constance J Jeffery

Abstract read
In one paragraph

Article in Nano reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Retracing the evolution of a modern periplasmic binding protein.Protein science : a publication of the Protein Society · 2023
    Article
  3. Nanotheranostics: application of nanosensors in diabetes management.Journal of diabetes and metabolic disorders · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Fluorescent Nanobiosensors for Sensing Glucose.Sensors (Basel, Switzerland) · 2018
    Review
  10. Redesign of LAOBP to bind novel l-amino acid ligands.Protein science : a publication of the Protein Society · 2018
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Clinical metabolomics: the next stage of clinical biochemistry.Blood transfusion = Trasfusione del sangue · 2012
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Constance J JefferyDepartment of Biological Sciences, Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes affects over 100 million people worldwide. Better methods for monitoring blood glucose levels are needed for improving disease management. Several labs have previously made glucose nanosensors by modifying members of the periplasmic ligand binding protein superfamily. This minireview summarizes recent developments in constructing new versions of these proteins that are responsive within the physiological range of blood glucose levels, employ new reporter groups, and/or are more robust. These experiments are important steps in the development of novel proteins that have the characteristics needed for an implantable glucose nanosensor for diabetes management: specificity for glucose, rapid response, sensitivity within the physiological range of glucose concentrations, reproducibility, and robustness.

Indexed as

biosensordiabetesglucosenanosensorperiplasmic ligand binding proteinprotein design

Identifiers

PMID22110874
PMCPMC3215197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.