Evidence map›Paper›PMID 22110859›Full record

ArticleNano reviews2010

Evaluation of the magnetic field requirements for nanomagnetic gene transfection.

A Fouriki, N Farrow, M A Clements, J Dobson

Abstract read
In one paragraph

Article in Nano reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Targeted Magnetic Nanotheranostics of Cancer.Molecules (Basel, Switzerland) · 2017
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A FourikiInstitute for Science & Technology in Medicine, Hartshill, Stoke-on-Trent, UK.
N Farrow
M A Clements
J Dobson

Funding

Medical Research Council G0701054
6 · The paper itself

Abstract

unlabelledThe objective of this work was to examine the effects of magnet distance (and by proxy, field strength) on nanomagnetic transfection efficiency.

methodsnon-viral magnetic nanoparticle-based transfection was evaluated using both static and oscillating magnet arrays.

resultsFluorescence intensity (firefly luciferase) of transfected H292 cells showed no increase using a 96-well NdFeB magnet array when the magnets were 5 mm from the cell culture plate or nearer. At 6 mm and higher, fluorescence intensity decreased systematically.

conclusionIn all cases, fluorescence intensity was higher when using an oscillating array compared to a static array. For distances closer than 5 mm, the oscillating system also outperformed Lipofectamine 2000™.

Indexed as

magnetic fieldmagnetic nanoparticle-based gene transfectionmagnetic nanoparticlesnon-viral gene delivery

Identifiers

PMID22110859
PMCPMC3215215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.