ArticlePloS one2011
GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Nuclear transfer leads to aberrant cell cycle regulation and translation, as determined by gene expression, and selection of mitochondrial DNA in porcine blastocysts.NAR molecular medicine · 2024Article
- Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer's Disease.Molecular neurobiology · 2024Review
- Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy.Frontiers in endocrinology · 2023Review
- Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease.Neural regeneration research · 2022Review
- Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases.Medicinal research reviews · 2022Review
- Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy.Frontiers in molecular neuroscience · 2022Article
- Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria.Frontiers in cellular neuroscience · 2022Article
- Review
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- AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.EMBO reports · 2020Article
- Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration.Frontiers in neuroscience · 2018Review
- Our Working Point of View of Tau Protein.Journal of Alzheimer's disease : JAD · 2018Review
- Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons.Translational psychiatry · 2017Article
- Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis.The EMBO journal · 2016Article
- Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease.Oxidative medicine and cellular longevity · 2015Review
- GSK-3β, a pivotal kinase in Alzheimer disease.Frontiers in molecular neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial trafficking deficits have been implicated in the pathogenesis of several neurological diseases, including Alzheimer's disease (AD). The Ser/Thre kinase GSK3β is believed to play a fundamental role in AD pathogenesis. Given that GSK3β substrates include Tau protein, here we studied the impact of GSK3β on mitochondrial trafficking and its dependence on Tau protein. Overexpression of GSK3β in neurons resulted in an increase in motile mitochondria, whereas a decrease in the activity of this kinase produced an increase in mitochondria pausing. These effects were dependent on Tau proteins, as Tau (-/-) neurons did not respond to distinct GSK3β levels. Furthermore, differences in GSK3β expression did not affect other parameters like mitochondria velocity or mitochondria run length. We conclude that GSK3B activity regulates mitochondrial axonal trafficking largely in a Tau-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.