Trial reportPloS one2011
An fMRI study on the role of serotonin in reactive aggression.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels.Scientific reports · 2016Trial
- Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD).Journal of neural transmission (Vienna, Austria : 1996) · 2014Trial
- A quasi-experimental study in sibling dyads: differential provocation-aggression patterns in the interactive taylor aggression paradigm.Frontiers in psychology · 2024Article
- Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization.Cognitive, affective & behavioral neuroscience · 2022Article
- Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.Human brain mapping · 2022Article
- Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices.Communications biology · 2022Article
- Punishment on Pause: Preliminary Evidence That Mindfulness Training Modifies Neural Responses in a Reactive Aggression Task.Frontiers in behavioral neuroscience · 2021Article
- Effect of Modulating DLPFC Activity on Antisocial and Prosocial Behavior: Evidence From a tDCS Study.Frontiers in psychology · 2020Article
- The neural correlates of alcohol-related aggression.Cognitive, affective & behavioral neuroscience · 2018Article
- The Effect of Cognitive Reappraisal on Reactive Aggression: An fMRI Study.Frontiers in psychology · 2018Article
- Anger-sensitive networks: characterizing neural systems recruited during aggressive social interactions using data-driven analysis.Social cognitive and affective neuroscience · 2017Article
- Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression.Current behavioral neuroscience reports · 2017Article
- Intention Modulates the Effect of Punishment Threat in Norm Enforcement via the Lateral Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding.Social cognitive and affective neuroscience · 2016Article
- Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.Frontiers in behavioral neuroscience · 2016Article
- Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Reducing proactive aggression through non-invasive brain stimulation.Social cognitive and affective neuroscience · 2015Article
- Out of control: evidence for anterior insula involvement in motor impulsivity and reactive aggression.Social cognitive and affective neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive aggression after interpersonal provocation is a common behavior in humans. Little is known, however, about brain regions and neurotransmitters critical for the decision-making and affective processes involved in aggressive interactions. With the present fMRI study, we wanted to examine the role of serotonin in reactive aggression by means of an acute tryptophan depletion (ATD). Participants performed in a competitive reaction time task (Taylor Aggression Paradigm, TAP) which entitled the winner to punish the loser. The TAP seeks to elicit aggression by provocation. The study followed a double-blind between-subject design including only male participants. Behavioral data showed an aggression diminishing effect of ATD in low trait-aggressive participants, whereas no ATD effect was detected in high trait-aggressive participants. ATD also led to reduced insula activity during the decision phase, independently of the level of provocation. Whereas previous reports have suggested an inverse relationship between serotonin level and aggressive behavior with low levels of serotonin leading to higher aggression and vice versa, such a simple relationship is inconsistent with the current data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.