ArticlePloS one2011
Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- TGFβ-dependent upregulation of OCIAD2 is essential for epithelial-to-mesenchymal transition during mesendoderm differentiation.Stem cell reports · 2026Article
- Integrative phosphoproteomics reveals kinase-mediated regulation of OCIAD1 and its roles in mitochondrial quality control.Frontiers in bioinformatics · 2026Article
- Asrij/OCIAD1 depletion reduces inflammatory microglial activation and ameliorates Aβ pathology in an Alzheimer's disease mouse model.Journal of neuroinflammation · 2025Article
- Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice.Frontiers in aging neuroscience · 2025Article
- Molecular characterization of human HSPCs with different cell fates in vivo using single-cell transcriptome analysis and lentiviral barcoding technology.Clinical and translational medicine · 2024Article
- The Endosomal Sorting Complex, ESCRT, has diverse roles in blood progenitor maintenance, lineage choice and immune response.Biology open · 2024Article
- Organelle dysfunction upon asrij depletion causes aging-like changes in mouse hematopoietic stem cells.Aging cell · 2022Article
- Regulation of energy metabolism in human pluripotent stem cells.Cellular and molecular life sciences : CMLS · 2021Review
- IntactBio-protocol · 2021Article
- Differential activation of JAK-STAT signaling reveals functional compartmentalization ineLife · 2021Article
- Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein.The Journal of membrane biology · 2021Article
- A Conserved Role for Asrij/OCIAD1 in Progenitor Differentiation and Lineage Specification Through Functional Interaction With the Regulators of Mitochondrial Dynamics.Frontiers in cell and developmental biology · 2021Article
- Spatial regulation and generation of diversity in signaling pathways.Journal of biosciences · 2021Review
- Single-cell RNA sequencing identifies novel cell types in Drosophila blood.Journal of genetics and genomics = Yi chuan xue bao · 2020Article
- The Role of Lozenge inMolecules and cells · 2020Review
- The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of theFrontiers in cell and developmental biology · 2020Review
- Proteomics of Asrij Perturbation inMolecular & cellular proteomics : MCP · 2019Article
- Review
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila.Developmental biology · 2018Article
Corrections and comments
- Erratum issuedSrivathsa, M S [corrected to Magadi, Srivathsa S]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. Mechanisms that modulate and integrate these signals are poorly understood. Here we report that mutation in a conserved endocytic protein Asrij affects signal transmission and causes aberrant lymph gland hematopoiesis. Mammalian Asrij (Ociad1) is expressed in stem cells of the blood vascular system and is implicated in several cancers. We found that Drosophila Asrij is a pan-hemocyte marker and localizes to a subset of endocytic vesicles. Loss of asrij causes hyperproliferation of lymph gland lobes coupled with increased hemocyte differentiation, thereby depleting the pool of quiescent hemocyte precursors. This co-relates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. Asrij null mutants also show excess specification of crystal cells that express the RUNX factor Lozenge (Lz), a target of Notch signaling. Asrij mutant lymph glands show increased N in sorting endosomes suggesting aberrant trafficking. In vitro assays also show impaired traffic of fluorescent probes in asrij null hemocytes. Taken together our data suggest a role for Asrij in causing increased Notch signaling thereby affecting hemocyte differentiation. Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.