ArticlePloS one2011
Fatal S. aureus hemorrhagic pneumonia: genetic analysis of a unique clinical isolate producing both PVL and TSST-1.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Genomic Characterization of a Rare Methicillin-Susceptible Staphylococcus aureus ST72 Isolate Co-Harboring Panton-Valentine Leukocidin and Toxic Shock Syndrome Toxin-1 Encoding Genes from Northern Vietnam.Current microbiology · 2026Article
- Fatal Panton-Valentine leukocidin-positive MSSA toxic shock syndrome: a call for rapid virulence detection and optimized antimicrobial therapy.Frontiers in cellular and infection microbiology · 2026Article
- Case Report: Fulminant shock due to PVL-positiveFrontiers in medicine · 2026Article
- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
- Decoding the evolutionary history of ST30Frontiers in microbiology · 2025Article
- Phenotypic and Molecular Characterization ofMicroorganisms · 2024Article
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- Carvacrol Essential Oil: A Natural Antibiotic against Zoonotic Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Genomic Investigation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Genotypic Characterization of Clinical Isolates ofPathogens (Basel, Switzerland) · 2021Article
- Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.mSphere · 2021Article
- Swine methicillin-resistantEmerging microbes & infections · 2020Article
- Pathogenic Effect ofFrontiers in microbiology · 2020Article
- The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.Journal of medical microbiology · 2019Article
- Evidence of latent molecular diversity determining the virulence of community-associated MRSA USA300 clones in mice.Immunity, inflammation and disease · 2018Article
- Comparative and molecular analysis of MRSA isolates from infection sites and carrier colonization sites.Annals of clinical microbiology and antimicrobials · 2018Article
- Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom.Emerging infectious diseases · 2018Article
- Necrotising pneumonia following influenza due to PVL-negativeBMJ case reports · 2017Article
- Whole-Genome Sequencing for the Investigation of a Hospital Outbreak of MRSA in China.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2008, an unusual strain of methicillin-sensitive Staphylococcus aureus (MSSA68111), producing both Panton-Valentine leukocidin (PVL) and toxic shock syndrome toxin-1 (TSST-1), was isolated from a fatal case of necrotizing pneumonia. Because PVL/TSST-1 co-production in S. aureus is rare, we characterized the molecular organization of these toxin genes in strain 68111. MSSA68111 carries the PVL genes within a novel temperate prophage we call ФPVLv68111 that is most similar, though not identical, to phage ФPVL--a phage type that is relatively rare worldwide. The TSST-1 gene (tst) in MSSA68111 is carried on a unique staphylococcal pathogenicity island (SaPI) we call SaPI68111. Features of SaPI68111 suggest it likely arose through multiple major recombination events with other known SaPIs. Both ФPVLv68111 and SaPI68111 are fully mobilizable and therefore transmissible to other strains. Taken together, these findings suggest that hypervirulent S. aureus have the potential to emerge worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.