ArticleInternational journal of biological sciences2011
Nitric oxide is involved in the upregulation of IFN-γ and IL-10 mRNA expression by CD8⁺ T cells during the blood stages of P. chabaudi AS infection in CBA/Ca mice.
Article in International journal of biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Biological Activity ofInternational journal of molecular sciences · 2026Article
- Testosterone Modulates Oxidative Stress in a Sexually Dimorphic Manner in CBA/Ca Mice Infected withInternational journal of molecular sciences · 2025Article
- Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer.Discover oncology · 2023Review
- DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected withInternational journal of molecular sciences · 2023Article
- Regulation of T Cells in Cancer by Nitric Oxide.Cells · 2021Review
- The Redox-Metabolic Couple of T Lymphocytes: Potential Consequences for Hypertension.Antioxidants & redox signaling · 2021Review
- 17β-Estradiol Is Involved in the Sexual Dimorphism of the Immune Response to Malaria.Frontiers in endocrinology · 2021Article
- Elimination of Hepatic RodentiScience · 2020Article
- A radical form of nitric oxide inhibits porcine circovirus type 2 replication in vitro.BMC veterinary research · 2019Article
- Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo.BMC veterinary research · 2017Article
- Beneficial effect of Punica granatum peel extract on murine malaria-induced spleen injury.BMC complementary and alternative medicine · 2016Article
- Sex hormones modulate the immune response to Plasmodium berghei ANKA in CBA/Ca mice.Parasitology research · 2015Article
- CD4+ T cell response correlates with naturally acquired antibodies against Plasmodium vivax tryptophan-rich antigens.Infection and immunity · 2015Article
- Gonadal steroids negatively modulate oxidative stress in CBA/Ca female mice infected with P. berghei ANKA.BioMed research international · 2014Article
- Innate and cellular immunology in parasitic diseases.International journal of biological sciences · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is involved in the clearance of several types of bacteria, viruses and parasites. Although the roles of NO and CD8⁺ T cells in the immune response to malaria have been extensively studied, their actual contributions during the blood stages of malaria infection remain unclear.In this work, we corroborate that serum NO levels are not associated with the in vivo elimination of the blood stages of Plasmodium chabaudi AS. In addition, we show that CD8⁺ T cells exhibit increased apoptosis and up regulate the expression of TNF-α mRNA on day 4 post-infection and IFN-γ and IL-10 mRNA on day 11 post-infection. Interestingly, only the levels of IFN-γ and IL-10 expression are affected when iNOS is inhibited with aminoguanidine (AG), suggesting that NO could be involved in the activation of CD8⁺ T cells during the blood stages of plasmodium infection.
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